Make Better Decisions

  • Uncover prior art in expired and abandoned patents
  • Obtain formulation and manufacturing information
  • Drug patents in 130+ countries

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
Federal Trade Commission
US Department of Justice

Generated: November 21, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title:Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and -1-oxoisoindolines and method of reducing TNF.alpha. levels
Abstract: Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF.alpha. in a mammal. A typical embodiment is 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline- .
Inventor(s): Muller; George W. (Bridgewater, NJ), Stirling; David I. (Branchburg, NJ), Chen; Roger Shen-Chu (Edison, NJ)
Assignee: Celgene Corporation (Summit, NJ)
Filing Date:Jan 14, 2005
Application Number:11/035,817
Claims:1. A compound of formula (I), or a salt or an optical isomer thereof: ##STR00006##

2. The compound of claim 1 having an optical purity of >95%.

3. An optical isomer of claim 1, which is (R)-3-(3-aminophthalimido)-3-methylpiperidine-2,6-dione or (S)-3-(3-aminophthalimido)-3-methylpiperidine-2,6-dione.

4. A pharmaceutical composition comprising a therapeutically effective amount of the compound, the salt or the optical isomer of claim 1, and a pharmaceutically acceptable carrier, diluent or excipient.

5. The pharmaceutical composition of claim 4 wherein the therapeutically effective amount is for reducing levels of TNF.alpha., or treating inflammatory, autoimmune, oncogenic or cancerous disease in a mammal.

6. The pharmaceutical composition of claim 4, wherein said composition is in the form of a tablet, a capsule, a lozenge, a cachet, a solution, a suspension, an emulsion, a powder, an aerosol, a spray, a suppository, a tampon, a pessary, a pastille, an ointment, a cream, a paste, a foam or a gel.

7. The pharmaceutical composition of claim 4, wherein said composition is suitable for oral, parenteral, topical, rectal, sublingual, buccal, vaginal, transdermal, or basal administration.

8. The pharmaceutical composition of claim 6, wherein said composition is in the form of a tablet.

9. The pharmaceutical composition of claim 6, wherein said composition is in the form of a capsule.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving leading biopharmaceutical companies globally:

Fish and Richardson
Harvard Business School
US Army

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:

Google Plus