.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 7,439,342

« Back to Dashboard

Details for Patent: 7,439,342

Title:Thrombopoietin mimetics
Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
Inventor(s): Duffy; Kevin J. (Collegeville, PA), Luengo; Juan I. (Collegeville, PA)
Assignee: Smith Kline Beecham Corp. (Philadelphia, PA)
Filing Date:Jan 08, 2007
Application Number:11/650,688
Claims:1. A compound represented by the following formula: ##STR00015## wherein AR is a polycyclic aromatic ring containing 3 to 16 carbon atoms and containing one or more heteroatoms, provided that when the number of carbon atoms is 3 the aromatic ring contains at least two heteroatoms and when the number of carbon atoms is 4 the aromatic ring contains at least one heteroatom, and optionally substituted with one or more substituents selected from the group consisting of: alkyl, trifluoromethyl and hydroxy; and R.sup.1 and R.sup.2 are independently selected from hydrogen and alkyl, provided that R.sup.1 and R.sup.2 are not both hydrogen; or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1 wherein: the AR contains one or two heteroatoms and is substituted with one or more substituents selected from the group consisting of: alkyl, trifluoromethyl and hydroxy; and R.sup.1 and R.sup.2 are independently selected from hydrogen and alkyl, provided that R.sup.1 and R.sup.2 are not both hydrogen; or a pharmaceutically acceptable salt thereof.

3. A compound according to claim 2 wherein: the AR is substituted with one or two substituents selected from the group consisting of: alkyl, trifluoromethyl and hydroxy; and R.sup.1 and R.sup.2 are independently selected from hydrogen and alkyl, provided that R.sup.1 and R.sup.2 are not both hydrogen; or a pharmaceutically acceptable salt thereof.

4. A compound according to claim 3 wherein: R.sup.1 and R.sup.2 are both methyl; or a pharmaceutically acceptable salt thereof.

5. A compound according to claim 3 wherein: one of R.sup.1 and R.sup.2 is hydrogen and the other is propyl; or a pharmaceutically acceptable salt thereof.

6. A pharmaceutical composition which comprises a compound of claim 1 and a pharmaceutically acceptable carrier.

7. A process for preparing a pharmaceutical composition containing a pharmaceutically acceptable carrier or diluent and an effective amount of the compound of claim 1, which process comprises bringing said compound into association with the pharmaceutically acceptable carrier or diluent.

8. A pharmaceutical composition which comprises a compound of claim 2 and a pharmaceutically acceptable carrier.

9. A pharmaceutical composition which comprises a compound of claim 3 and a pharmaceutically acceptable carrier.

10. A pharmaceutical composition which comprises a compound of claim 4 and a pharmaceutically acceptable carrier.

11. A pharmaceutical composition which comprises a compound of claim 5 and a pharmaceutically acceptable carrier.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc