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Details for Patent: 7,410,652

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Details for Patent: 7,410,652

Title:Controlled release and taste masking oral pharmaceutical composition
Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Inventor(s): Villa; Roberto (Lecco, IT), Pedrani; Massimo (Cignese, IT), Ajani; Mauro (Milan, IT), Fossati; Lorenzo (Milan, IT)
Assignee: Cosmo Technologies Limited (Wicklow, IE)
Filing Date:Mar 20, 2006
Application Number:11/378,378
Claims:1. A controlled release oral pharmaceutical composition in a tablet form containing mesalamine as the active ingredient, consisting essentially of: a) a matrix, consisting of lipophilic compounds with a melting point lower than 90.degree. C. in which the active ingredient is at least partially dispersed, said lipophilic compounds being a combination of at least one wax and at least one saturated fatty acid or unsaturated fatty acid; b) a hydrophilic matrix in which the lipophilic matrix is dispersed, said hydrophilic matrix consisting of carboxyalkylcellulose; and c) a matrix consisting of amphiphilic compounds being selected from the group consisting of polar lipids of type I, polar lipids of type II and glycols partially etherified with C1-C4 alkyl chains, in which the active ingredient is at least partially dispersed, said matrix of amphiphilic compounds being dispersed in the hydrophilic matrix, wherein, the matrix of lipophilic compounds, the matrix of hydrophilic compounds, and the matrix of amphiphilic compounds, in combination, provide controlled release.

2. The composition as claimed in claim 1, wherein the saturated fatty acid is selected from the group consisting of palmitic, stearic, myristic, lauric, laurilic or oleic acids, and mixtures thereof.

3. The composition as claimed in claim 1, wherein the saturated fatty acid is stearic acid.

4. The composition as claimed in claim 1, wherein the melting point of the lipophilic matrix is from 40.degree. C. to 90.degree. C.
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