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Details for Patent: 7,407,932

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Details for Patent: 7,407,932

Title:Methods for glucagon suppression using modified exendins
Abstract: Methods for use of an exendin, an exendin agonist, or a modified exendin or exendin agonist having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, for lowering glucagon levels and/or suppressing glucagon secretion in a subject are provided. These methods are useful in treating hyperglucagonemia and other conditions that would be benefited by lowering plasma glucgon or suppressing glucagon secretion.
Inventor(s): Young; Andrew A. (San Diego, CA), Gedulin; Bronislava (San Diego, CA)
Assignee: Amylin Pharmaceuticals, Inc. (San Diego, CA)
Filing Date:Oct 19, 2006
Application Number:11/584,114
Claims:1. A modified exendin agonist peptide or exendin agonist analog peptide wherein one or more amino acid residues is acylated with a dicarboxylic acid; wherein the amino acid residues are an internal lysine residue, an N-terminal amino acid residue, a C-terminal amino acid residue, or a combination of two or more thereof.

2. The peptide of claim 1, wherein the acylated amino acid residue comprises a side chain having a dicarboxylic acid group.

3. The peptide of claim 1, wherein the acylated amino acid residue is a C-terminal lysine residue.

4. The peptide of claim 1, wherein the peptide comprises a plurality of amino acid residues comprising dicarboxylic groups.

5. The peptide of claim 1, wherein the dicarboxylic group is linked to an epsilon amino group of a lysine residue.

6. The peptide of claim 1, wherein the peptide comprises an amino acid sequence according to any of SEQ ID NOs. 1-239.

7. An exendin-4 agonist peptide wherein one or more amino acid residues is acylated with a dicarboxylic acid; wherein the amino acid residues are an internal lysine residue, an N-terminal amino acid residue, a C-terminal amino acid residue, or a combination of two or more thereof.
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