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Details for Patent: 7,375,137

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Details for Patent: 7,375,137

Title:Methods of treating cancer with HDAC inhibitors
Abstract: The present invention provides methods of treating cancers, chemoprevention, selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.
Inventor(s): Bacopoulos; Nicholas G. (New York, NY), Chiao; Judy H. (Berkeley Heights, NJ), Miller; Thomas A. (New York, NY), Paradise; Carolyn M. (Cortland Manor, NY), Richon; Victoria M. (Rye, NY)
Assignee: Merck HDAC Research, LLC (Boston, MA)
Filing Date:Mar 28, 2006
Application Number:11/391,971
Claims:1. A method of treating mesothelioma, said method comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising suberoylanilide hydroxamic acid (SAHA), represented by the structure: ##STR00063## and a pharmaceutically acceptable carrier or diluent, thereby treating mesothelioma in said subject.

2. The method of claim 1, wherein the pharmaceutical composition is administered orally.

3. The method of claim 2, wherein said composition is contained within a gelatin capsule.

4. The method of claim 3, wherein said carrier or diluent is microcrystalline cellulose.

5. The method of claim 4, further comprising sodium croscarmellose as a disintegrating agent.

6. The method of claim 5, further comprising magnesium stearate as a lubricant.

7. The method of claim 2, wherein said composition is administered to the subject at a total daily dosage of between 25-4000 mg/m.sup.2.

8. The method of claim 2, wherein said composition is administered once-daily, twice-daily or three times-daily.

9. The method of claim 8, wherein said composition is administered once daily at a dose of 200-600 mg.

10. The method of claim 8, wherein said composition is administered twice daily at a dose of 200-400 mg.

11. The method of claim 8, wherein said composition is administered twice daily at a dose of 200-400 mg intermittently.

12. The method of claim 11, wherein said composition is administered three to five days per week.

13. The method of claim 11, wherein said composition is administered three days a week.

14. The method of claim 13, wherein said composition is administered at a dose of 200 mg.

15. The method of claim 13, wherein said composition is administered at a dose of 300 mg.

16. The method of claim 13, wherein said composition is administered at a dose of 400 mg.

17. The method of claim 2, wherein said composition is administered three times-daily.

18. A method of treating mesothelioma, said method comprising administering orally to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising suberoylanilide hydroxamic acid (SAHA) represented by the structure: ##STR00064## and a pharmaceutically acceptable carrier or diluent, thereby treating mesothelioma in said subject.

19. The method of claim 18, wherein said composition is contained within a gelatin capsule.

20. The method of claim 19, wherein said carrier or diluent is microcrystalline cellulose.

21. The method of claim 20, further comprising sodium croscarmellose as a disintegrating agent.

22. The method of claim 21, further comprising magnesium stearate as a lubricant.

23. The method of claim 18, wherein said composition is administered to the subject at a total daily dosage of between 25-4000 mg/m.sup.2.

24. The method of claim 18, wherein said composition is administered once-daily, twice-daily or three times-daily.

25. The method of claim 24, wherein said composition is administered once daily at a dose of 200-600 mg.

26. The method of claim 24, wherein said composition is administered twice daily at a dose of 200-400 mg.

27. The method of claim 24, wherein said composition is administered twice daily at a dose of 200-400 mg intermittently.

28. The method of claim 27, wherein said composition is administered three to five days per week.

29. The method of claim 27, wherein said composition is administered three days a week.

30. The method of claim 29, wherein said composition is administered at a dose of 200 mg.

31. The method of claim 29, wherein said composition is administered at a dose of 300 mg.

32. The method of claim 29, wherein said composition is administered at a dose of 400 mg.

33. The method of claim 18, wherein said composition is administered three times-daily.

34. A method of treating mesothelioma, said method comprising administering to a subject in need thereof a therapeutically effective daily dose totaling up to 800 mg of a pharmaceutical composition comprising suberoylanilide hydroxamic acid (SAHA), represented by the structure: ##STR00065## and a pharmaceutically acceptable carrier or diluent, thereby treating mesothelioma in said subject.

35. The method of claim 34, wherein the pharmaceutical composition is administered orally.

36. The method of claim 35, wherein said composition is contained within a gelatin capsule.

37. The method of claim 36, wherein said carrier or diluent is microcrystalline cellulose.

38. The method of claim 37, further comprising sodium croscarmellose as a disintegrating agent.

39. The method of claim 38, further comprising magnesium stearate as a lubricant.

40. The method of claim 35, wherein said composition is administered once-daily, twice-daily or three times-daily.

41. The method of claim 40, wherein said composition is administered once daily at a dose of 200-600 mg.

42. The method of claim 40, wherein said composition is administered twice daily at a dose of 200-400 mg.

43. The method of claim 40, wherein said composition is administered twice daily at a dose of 200-400 mg intermittently.

44. The method of claim 43, wherein said composition is administered three to five days per week.

45. The method of claim 43, wherein said composition is administered three days a week.

46. The method of claim 45, wherein said composition is administered at a dose of 200 mg.

47. The method of claim 45, wherein said composition is administered at a dose of 300 mg.

48. The method of claim 45, wherein said composition is administered at a dose of 400 mg.

49. The method of claim 35, wherein said composition is administered three times-daily.

50. The method of claim 26, wherein said composition is administered at a dose of 200 mg.

51. The method of claim 26, wherein said composition is administered at a dose of 300 mg.

52. The method of claim 26, wherein said composition is administered at a dose of 400 mg.

53. The method of claim 27, wherein said composition is administered at a dose of 200 mg.

54. The method of claim 27, wherein said composition is administered at a dose of 300 mg.

55. The method of claim 27, wherein said composition is administered at a dose of 400 mg.

56. A method of treating mesothelioma, said method comprising administering orally 300 mg twice daily for 3 days per week to a subject in need thereof a pharmaceutical composition comprising suberoylanilide hydroxamic acid (SAHA) represented by the structure: ##STR00066## as the active ingredient and a pharmaceutically acceptable carrier or diluent, thereby treating mesothelioma in said subject.
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