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Details for Patent: 7,371,761

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Details for Patent: 7,371,761

Title:Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P.sub.4-P-M-M.sub.4I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
Inventor(s): Pinto; Donald J. P. (Churchville, PA), Quan; Mimi L. (Yardley, PA), Orwat; Michael J. (New Hope, PA), Li; Yun-Long (Wilmington, DE), Han; Wei (Yardley, PA), Qiao; Jennifer X. (Princeton, NJ), Lam; Patrick Y. S. (Chadds Ford, PA), Koch; Stephanie L (Newark, DE)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Filing Date:Jan 16, 2007
Application Number:11/623,367
Claims:1. A compound of Formula I: ##STR00238## or a stereoisomer or pharmaceutically acceptable salt thereof, wherein; ring M, including P.sub.1, P.sub.2, M.sub.1, and M.sub.2, is substituted with 0-2 R.sup.1a and is ##STR00239## ring P, including P.sub.1, P.sub.2, and P.sub.3, is ##STR00240## M.sub.4 is -A-B; P.sub.4 is -G.sub.1-G; G is a group of Formula IIa or IIb: ##STR00241## ring D, including the two atoms of Ring E to which it is attached, is a 5-6 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O).sub.p; ring D is substituted with 0-2 R and there are 0-3 ring double bonds; E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and is substituted with 1-2 R; alternatively, ring D is absent and ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, triazolyl, thienyl, and thiazolyl, and ring E is substituted with 1-2 R; alternatively, ring D is absent and ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, triazolyl, thienyl, and thiazolyl, and ring E is substituted with 1 R and with a 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, wherein the 5-6 membered heterocycle is substituted with 0-1 carbonyl and 1-2 R and there are 0-3 ring double bonds; R is selected from H, C.sub.1-4 alkyl, F, Cl, Br, I, OH, OCH.sub.3, OCH.sub.2CH.sub.3, OCH(CH.sub.3).sub.2, OCH.sub.2CH.sub.2CH.sub.3, CN, C(.dbd.NR.sup.8)NR.sup.7R.sup.9, NHC(.dbd.NR.sup.8)NR.sup.7R.sup.9, ONHC(.dbd.NR.sup.8)NR.sup.7R.sup.9, NR.sup.8CH(.dbd.NR.sup.7), NH.sub.2, NH(C.sub.1-3 alkyl), N(C.sub.1-3 alkyl).sub.2, C(.dbd.NH)NH.sub.2, CH.sub.2NH.sub.2, CH.sub.2NH(C.sub.1-3 alkyl), CH.sub.2N(C.sub.1-3 alkyl).sub.2, CH.sub.2CH.sub.2NH.sub.2, CH.sub.2CH.sub.2NH(C.sub.1-3 alkyl), CH.sub.2CH.sub.2N(C.sub.1-3 alkyl).sub.2, (CR.sup.8R.sup.9).sub.tC(O)H, (CR.sup.8R.sup.9).sub.tC(O)R.sup.2c, (CR.sup.8R.sup.9).sub.tNR.sup.7R.sup.8, (CR.sup.8R.sup.9).sub.tC(O)NR.sup.7R.sup.8, (CR.sup.8R.sup.9).sub.tNR.sup.7C(O)R.sup.7, (CR.sup.8R.sup.9).sub.tOR.sup.3, (CR.sup.8R.sup.9).sub.tS(O).sub.pNR.sup.7R.sup.8, (CR.sup.8R.sup.9).sub.tNR.sup.7S(O).sub.pR.sup.7, (CR.sup.8R.sup.9).sub.tSR.sup.3, (CR.sup.8R.sup.9).sub.tS(O)R.sup.3, (CR.sup.8R.sup.9).sub.tS(O).sub.2R.sup.3, and OCF.sub.3; alternatively, when 2 R groups are attached to adjacent atoms, they combine to form methylenedioxy or ethylenedioxy; A is a C.sub.3-10 carbocycle substituted with 0-2 R.sup.4; B is ##STR00242## Q is C.dbd.O; ring Q is a 6 membered monocyclic ring, wherein: 1-2 double bonds are present within the ring and the ring is substituted with 0-2 R.sup.4a; X is absent; G.sub.1 is absent or is selected from (CR.sup.3R.sup.3a).sub.1-5, (CR.sup.3R.sup.3a).sub.0-2CR.sup.3.dbd.CR.sup.3(CR.sup.3R.sup.3a).sub.0-2- , (CR.sup.3R.sup.3a).sub.0-2C.ident.C(CR.sup.3R.sup.3a).sub.0-2, (CR.sup.3R.sup.3a).sub.uC(O)(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uC(O)O(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uOC(O)(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uO(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uN.sup.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uC(O)N.sup.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uN.sup.3bC(O)(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uOC(O)N.sup.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uN.sup.3bC(O)O(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uN.sup.3bC(O)N.sup.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uN.sup.3bC(S)N.sup.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uS(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uS(O)(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uS(O).sub.2(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uS(O)N.sup.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uN.sup.3bS(O).sub.2(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uS(O).sub.2N.sup.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uN.sup.3bS(O).sub.2N.sup.3b(CR.sup.3R.sup.3a).sub.- w, (CR.sup.3R.sup.3a).sub.uNR.sup.3e(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uC(O)(CR.sup.3R.sup.3a).sub.uC(O)(CR.sup.3R.sup.3a- ).sub.w, (CR.sup.3R.sup.3a).sub.uNR.sup.3b(CR.sup.3R.sup.3a).sub.uC(O)NR.s- up.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uNR.sup.3bC(O)(CR.sup.3R.sup.3a).sub.uC(O)(CR.sup.- 3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uC(O)(CR.sup.3R.sup.3a).sub.uC(O)NR.sup.3b(CR.sup.- 3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uNR.sup.3bC(O)(CR.sup.3R.sup.3a).sub.uC(O)NR.sup.3- b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uS(O)NR.sup.3bC(O)(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uC(O)NR.sup.3bS(O).sub.2(CR.sup.3R.sup.3a).sub.w, and (CR.sup.3R.sup.3a).sub.uS(O).sub.2NR.sup.3bC(O)NR.sup.3bCR.sup.3R.sup- .3a).sub.w, wherein u+w total 0, 1, 2, 3, or 4, provided that G.sub.1 does not form an N--S, NCH.sub.2N, NCH.sub.2O, or NCH.sub.2S bond with either group to which it is attached; R.sup.1a, at each occurrence, is selected from H, --(CR.sup.3R.sup.3a).sub.r--R.sup.1b, --(CR.sup.3R.sup.3a).sub.r--CR.sup.3R.sup.1bR.sup.1b, --(CR.sup.3R.sup.3a).sub.r--O--(CR.sup.3R.sup.3a).sub.r--R.sup.1b, --C.sub.2-6 alkenylene-R.sup.1b, --C.sub.2-6 alkynylene-R.sup.1b, --(CR.sup.3R.sup.3a).sub.r--C(.dbd.NR.sup.1b)NR.sup.3R.sup.1b, NR.sup.3CR.sup.3R.sup.3aR.sup.1c, OCR.sup.3R.sup.3aR.sup.1c, SCR.sup.3R.sup.3aR.sup.1c, NR.sup.3(CR.sup.3R.sup.3a).sub.2(CR.sup.3R.sup.3a).sub.tR.sup.1b, C(O)NR.sup.2(CR.sup.3R.sup.3a).sub.2(CR.sup.3R.sup.3a).sub.tR.sup.1b, CO.sub.2(CR.sup.3R.sup.3a).sub.2(CR.sup.3R.sup.3a).sub.tR.sup.1b, O(CR.sup.3R.sup.3a).sub.2(CR.sup.3R.sup.3a).sub.tR.sup.1b, S(CR.sup.3R.sup.3a).sub.2(CR.sup.3R.sup.3a).sub.tR.sup.1b, S(O).sub.p(CR.sup.3R.sup.3a).sub.rR.sup.1d, O(CR.sup.3R.sup.3a).sub.rR.sup.1d, NR.sup.3(CR.sup.3R.sup.3a).sub.rR.sup.1d, OC(O)NR.sup.3(CR.sup.3R.sup.3a).sub.rR.sup.1d, NR.sup.3C(O)NR.sup.3(CR.sup.3R.sup.3a).sub.rR.sup.1d, NR.sup.3C(O)O(CR.sup.3R.sup.3a).sub.rR.sup.1d, and NR.sup.3C(O)(CR.sup.3R.sup.3a).sub.rR.sup.1d, provided that R.sup.1a forms other than an N-halo, N--S, O--O, or C--CN bond; alternatively, when two R.sup.1a groups are attached to adjacent atoms, together with the atoms to which they are attached they form a 5-7 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, this ring being substituted with 0-2 R.sup.4b and 0-3 ring double bonds; R.sup.1b is selected from H, C.sub.1-3 alkyl, F, Cl, Br, I, --CN, --NO.sub.2 , --CHO, (CF.sub.2).sub.rCF.sub.3, (CR.sup.3R.sup.3a).sub.rOR.sup.2, NR.sup.2R.sup.2a, C(O)R.sup.2b, CO.sub.2R.sup.2b, OC(O)R.sup.2, (CF.sub.2).sub.rCO.sub.2R.sup.2a, S(O).sub.pR.sup.2b, NR.sup.2(CH.sub.2).sub.rOR.sup.2, C(.dbd.NR.sup.2c)NR.sup.2R.sup.2a, NR.sup.2C(O)R.sup.2b, NR.sup.2C(O)NHR.sup.2, NR.sup.2C(O).sub.2R.sup.2a, OC(O)NR.sup.2R.sup.2a, C(O)NR.sup.2R.sup.2a, C(O)NR.sup.2(CH.sub.2).sub.rOR.sup.2, SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2R.sup.2, C(O)NR.sup.2SO.sub.2R.sup.2, C.sub.3-6 carbocycle substituted with 0-2 R.sup.4b, and 5-10 membered heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b, provided that R.sup.1b forms other than an O--O, N-halo, N--S, or C--CN bond; R.sup.1c is selected from H, CH(CH.sub.2OR.sup.2).sub.2, C(O)R.sup.2c, C(O)NR.sup.2R.sup.2a, S(O)R.sup.2, S(O).sub.2R.sup.2, and SO.sub.2NR.sup.2R.sup.2a; R.sup.1d is selected from C.sub.3-6 carbocycle substituted with 0-2 R.sup.4b and 5-10 membered heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b, provided that R.sup.1d forms other than an N--S bond; R.sup.2, at each occurrence, is selected from H, CF.sub.3, C.sub.1-6 alkyl, benzyl, --(CH.sub.2).sub.r--C.sub.3-10 carbocycle substituted with 0-2 R.sup.4b, and --(CH.sub.2).sub.r-5-10 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.2a, at each occurrence, is selected from H, CF.sub.3, C.sub.1-6 alkyl, benzyl, --(CH.sub.2).sub.r--C.sub.3iO carbocycle substituted with 0-2 R.sup.4b, and --(CH.sub.2).sub.r-5-10 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; alternatively, R.sup.2 and R.sup.2a, together with the atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-2 R.sup.4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.2b, at each occurrence, is selected from CF.sub.3, C.sub.1-4 alkoxy substituted with 0-2 R.sup.4b, C.sub.1-6 alkyl substituted with 0-2 R.sup.4b, --(CH.sub.2).sub.r--C.sub.3-10 carbocycle substituted with 0-2 R.sup.4b, and --(CH.sub.2).sub.r-5-10 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.2c, at each occurrence, is selected from CF.sub.3, OH, C.sub.1-4 alkoxy, C.sub.1-6 alkyl, --(CH.sub.2).sub.r--C.sub.3-10 carbocycle substituted with 0-2 R.sup.4b, and --(CH.sub.2).sub.r-5-10 membered heterocycle containing from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.3, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, and phenyl; R.sup.3a, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, and phenyl; alternatively, R.sup.3 and R.sup.3a, together with the nitrogen atom to which they are attached, combine to form a 5 or 6 membered saturated, partially unsaturated, or unsaturated ring consisting of: carbon atoms, the nitrogen atom to which R.sup.3 and R.sup.3a are attached, and 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.3b, at each occurrence, is selected from H, C.sub.1-6 alkyl substituted with 0-2 R.sup.1a, C.sub.2-6 alkenyl substituted with 0-2 R.sup.1a, C.sub.2-6 alkynyl substituted with 0-2 R.sup.1a, --(C.sub.0-4 alkyl)-5-10 membered carbocycle substituted with 0-3 R.sup.1a, and --(C.sub.0-4 alkyl)-5-10 membered heterocycle substituted with 0-3 R.sup.1a and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.3c, at each occurrence, is selected from CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, and phenyl; R.sup.3d, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C.sub.1-4 alkyl-phenyl, and C(.dbd.O)R.sup.3c; R.sup.3e, at each occurrence, is selected from H, SO.sub.2NHR.sup.3, SO.sub.2NR.sup.3R.sup.3, C(O)R.sup.3, C(O)NHR.sup.3, C(O)OR.sup.3f, S(O)R.sup.3f, S(O).sub.2R.sup.3f, C.sub.1-6 alkyl substituted with 0-2 R.sup.1a, C.sub.2-6 alkenyl substituted with 0-2 R.sup.1a, C.sub.2-6 alkynyl substituted with 0-2 R.sup.1a, --(C.sub.0-4 alkyl)-5-10 membered carbocycle substituted with 0-3 R.sup.1a, and --(C.sub.0-4 alkyl)-5-10 membered heterocycle substituted with 0-3 R.sup.1a and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.3f, at each occurrence, is selected from: C.sub.1-6 alkyl substituted with 0-2 R.sup.1a, C.sub.2-6 alkenyl substituted with 0-2 R.sup.1a, C.sub.2-6 alkynyl substituted with 0-2 R.sup.1a, --(C.sub.0-4 alkyl)-5-10 membered carbocycle substituted with 0-3 R.sup.1a, and --(C.sub.0-4 alkyl)-5-10 membered heterocycle substituted with 0-3 R.sup.1a and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.4, at each occurrence, is selected from H, .dbd.O, (CR.sup.3R.sup.3a).sub.rOR.sup.2, F, Cl, Br, I, C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.rCN, (CR.sup.3R.sup.3a).sub.rNO.sub.2, (CR.sup.3R.sup.3a).sub.rNR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rC(O)R.sup.2c, (CR.sup.3R.sup.3a).sub.rNR.sup.2C(O)R.sup.2b, (CR.sup.3R.sup.3a).sub.rC(O)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNR.sup.2C(O)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rC(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rC(.dbd.NS(O).sub.2R.sup.5)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNHC(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rC(O)NHC(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rSO.sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNR.sup.2SO.sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNR.sup.2SO.sub.2--C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.rNR.sup.2SO.sub.2R.sup.5, (CR.sup.3R.sup.3a).sub.rS(O).sub.pR.sup.5a, (CR.sup.3R.sup.3a).sub.r(CF.sub.2).sub.rCF.sub.3, NHCH.sub.2R.sup.1c, OCH.sub.2R.sup.1c, SCH.sub.2R.sup.1c, NH(CH.sub.2).sub.2(CH.sub.2).sub.tR.sup.1b, O(CH.sub.2).sub.2(CH.sub.2).sub.tR.sup.1b, S(CH.sub.2).sub.2(CH.sub.2).sub.tR.sup.1b, (CR.sup.3R.sup.3a).sub.r-5-6 membered carbocycle substituted with 0-1 R.sup.5, and a (CR.sup.3R.sup.3a).sub.r-5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5; R.sup.4a, at each occurrence, is selected from H, .dbd.O, (CR.sup.3R.sup.3a).sub.rOR.sup.2, (CR.sup.3R.sup.3a).sub.rF, (CR.sup.3R.sup.3a).sub.rBr, (CR.sup.3R.sup.3a).sub.rCl, C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.rCN, (CR.sup.3R.sup.3a).sub.rNO.sub.2, (CR.sup.3R.sup.3a).sub.rNR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rC(O)R.sup.2c, (CR.sup.3R.sup.3a).sub.rNR.sup.2C(O)R.sup.2b, (CR.sup.3R.sup.3a).sub.rC(O)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a.sub.rN.dbd.CHOR.sup.3, (CR.sup.3R.sup.3a).sub.rC(O)NH(CH.sub.2).sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNR.sup.2C(O)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rC(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNHC(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rSO.sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNR.sup.2SO.sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNR.sup.2SO.sub.2--C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.rC(O)NHSO.sub.2--C.sub.1-4 alkyl, (CR.sup.3R.sup.3a)NR.sup.2SO.sub.2R.sup.5, (CR.sup.3R.sup.3a).sub.rS(O).sub.pR.sup.5a, (CR.sup.3R.sup.3a).sub.r(CF.sub.2).sub.rCF.sub.3, (CR.sup.3R.sup.3a).sub.r-5-6 membered carbocycle substituted with 0-1 R.sup.5, and a (CR.sup.3R.sup.3a).sub.r-5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5; R.sup.4b, at each occurrence, is selected from H, .dbd.O, (CH.sub.2).sub.rOR.sup.3, (CH.sub.2).sub.rF, (CH.sub.2).sub.rCl, (CH.sub.2).sub.rBr, (CH.sub.2).sub.rI, C.sub.1-4 alkyl, (CH.sub.2).sub.rCN, (CH.sub.2).sub.rNO.sub.2, (CH.sub.2).sub.rNR.sup.3R.sup.3a, (CH.sub.2).sub.rC(O)R.sup.3, (CH.sub.2).sub.rC(O)OR.sup.3c, (CH.sub.2).sub.rNR.sup.3C(O)R.sup.3a, (CH.sub.2).sub.r--C(O)NR.sup.3R.sup.3a,

(CH.sub.2).sub.rNR.sup.3C(O)NR.sup.3R.sup.3a, (CH.sub.2).sub.r--C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, (CH.sub.2).sub.rSO.sub.2NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3SO.sub.2NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3SO.sub.2--C.sub.1-4alkyl, (CH.sub.2).sub.rNR.sup.3SO.sub.2CF.sub.3, (CH.sub.2).sub.rNR.sup.3SO.sub.2-phenyl, (CH.sub.2).sub.rS(O).sub.pCF.sub.3, (CH.sub.2).sub.rS(O).sub.p--C.sub.1-4 alkyl, (CH.sub.2).sub.rS(O).sub.p-phenyl, and (CH.sub.2).sub.r(CF.sub.2).sub.rCF.sub.3; R.sup.4c, at each occurrence, is selected from H, C.sub.1-4 alkyl (CR.sup.3R.sup.3a).sub.r1OR.sup.2, (CR.sup.3R.sup.3a).sub.r1F, (CR.sup.3R.sup.3a).sub.r1Br, (CR.sup.3R.sup.3a).sub.r1Cl, (CR.sup.3R.sup.3a).sub.r1CN, (CR.sup.3R.sup.3a).sub.r1NO.sub.2, (CR.sup.3R.sup.3a).sub.r1NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rC(O)R.sup.2c, (CR.sup.3R.sup.3a).sub.r1NR.sup.2C(O)R.sup.2b, (CR.sup.3R.sup.3a).sub.rC(O)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1N.dbd.CHOR.sup.3, (CR.sup.3R.sup.3a).sub.rC(O)NH(CH.sub.2).sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1NR.sup.2C(O)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1C(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1NHC(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rSO.sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1NR.sup.2SO.sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1NR.sup.2SO.sub.2--C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.rC(O)NHSO.sub.2--C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.r1NR.sup.2SO.sub.2R.sup.5, (CR.sup.3R.sup.3a).sub.rS(O).sub.pR.sup.5a, (CR.sup.3R.sup.3a).sub.r(CF.sub.2).sub.rCF.sub.3, (CR.sup.3R.sup.3a).sub.r-5-6 membered carbocycle substituted with 0-1 R.sup.5, and a (CR.sup.3R.sup.3a).sub.r-5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5; R.sup.5, at each occurrence, is selected from H, C.sub.1-6 alkyl, .dbd.O, (CH.sub.2).sub.rOR.sup.3, F, Cl, Br, I, --CN, NO.sub.2, (CH.sub.2).sub.rNR.sup.3R.sup.3a, (CH.sub.2).sub.rC(O)R.sup.3, (CH.sub.2).sub.rC(O)OR.sup.3c, (CH.sub.2).sub.rNR.sup.3C(O)R.sup.3a, (CH.sub.2).sub.rC(O)NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3C(O)NR.sup.3R.sup.3a, (CH.sub.2).sub.rCH(.dbd.NOR.sup.3d), (CH.sub.2).sub.rC(.dbd.NR.sup.3)NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, (CH.sub.2).sub.rSO.sub.2NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3SO.sub.2NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3SO.sub.2--C.sub.1-4alkyl, (CH.sub.2).sub.rNR.sup.3SO.sub.2CF.sub.3, (CH.sub.2).sub.rNR.sup.3SO.sub.2-phenyl, (CH.sub.2).sub.rS(O).sub.pCF.sub.3, (CH.sub.2).sub.rS(O).sub.p--C.sub.1-4 alkyl, (CH.sub.2).sub.rS(O).sub.p-phenyl, (CF.sub.2).sub.rCF.sub.3, phenyl substituted with 0-2 R.sup.6, naphthyl substituted with 0-2 R.sup.6, and benzyl substituted with 0-2 R.sup.6; R.sup.5a, at each occurrence, is selected from C.sub.1-6 alkyl, (CH.sub.2).sub.rOR.sup.3, (CH.sub.2).sub.rNR.sup.3R.sup.3a, (CH.sub.2).sub.rC(O)R.sup.3, (CH.sub.2).sub.rC(O)OR.sup.3c, (CH.sub.2).sub.rNR.sup.3C(O)R.sup.3a, (CH.sub.2).sub.rC(O)NR.sup.3R.sup.3a, (CF.sub.2).sub.rCF.sub.3, phenyl substituted with 0-2 R.sup.6, naphthyl substituted with 0-2 R.sup.6, and benzyl substituted with 0-2 R.sup.6, provided that R.sup.5a does not form a S--N or S(O).sub.p--C(O) bond; R.sup.6, at each occurrence, is selected from H, OH, (CH.sub.2).sub.rOR.sup.2, halo, C.sub.1-4 alkyl, CN, NO.sub.2, (CH.sub.2).sub.rNR.sup.2R.sup.2a, (CH.sub.2).sub.rC(O)R.sup.2b, NR.sup.2C(O)R.sup.2b, NR.sup.2C(O)NR.sup.2R.sup.2a, C(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2NR.sup.2R.sup.2a, and NR.sup.2SO.sub.2C.sub.1-4 alkyl; R.sup.7, at each occurrence, is selected from H, OH, C.sub.1-6 alkyl, C.sub.1-6 alkyl-C(O)--, C.sub.1-6 alkyl-O--, (CH.sub.2).sub.n-phenyl, C.sub.1-4 alkyl-OC(O)--, C.sub.6-10 aryl-O--, C.sub.6-10 aryl-OC(O)--, C.sub.6-10 aryl-CH.sub.2--C(O)--, C.sub.1-4 alkyl-C(O)O--C.sub.1-4 alkyl-OC(O)--, C.sub.6-10 aryl-C(O)O--C.sub.1-4 alkyl-OC(O)--, C.sub.1-6 alkyl-NH.sub.2--C(O)--, phenyl-NH.sub.2--C(O)--, and phenyl-C.sub.1-4 alkyl-C(O)--; R.sup.8, at each occurrence, is selected from H, C.sub.1-6 alkyl, and (CH.sub.2).sub.n-phenyl; alternatively, R.sup.7 and R.sup.8, when attached to the same nitrogen, combine to form a 5-10 membered heterocyclic ring consisting of carbon atoms and 0-2 additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.9, at each occurrence, is selected from H, C.sub.1-6 alkyl, and (CH.sub.2).sub.n-phenyl; n, at each occurrence, is selected from 0, 1, 2, and 3; p, at each occurrence, is selected from 0, 1, and 2; r, at each occurrence, is selected from 0, 1, 2, 3, 4, 5, and 6; r1, at each occurrence, is selected from 1, 2, 3, 4, 5, and 6; and t, at each occurrence, is selected from 0, 1, 2, and 3.

2. A compound according to claim 1, wherein: G is a group of Formula IIa or IIb: ##STR00243## ring D, including the two atoms of Ring E to which it is attached, is a 5-6 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O).sub.p; ring D is substituted with 0-2 R and there are 0-3 ring double bonds; E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and is substituted with 1-2 R; alternatively, ring D is absent, and ring E is selected from phenyl, pyridyl, pyrimidyl, and thienyl, and ring E is substituted with 1-2 R; alternatively, ring D is absent, ring E is selected from phenyl, pyridyl, and thienyl, and ring E is substituted with 1 R and substituted with a 5 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, wherein the 5 membered heterocycle is substituted with 0-1 carbonyl and 1-2 R and there are 0-3 ring double bonds; R is selected from H, C.sub.1-4 alkyl, F, Cl, OH, OCH.sub.3, OCH.sub.2CH.sub.3, OCH(CH.sub.3).sub.2, CN, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH, C(.dbd.NH)NHOCH.sub.3, NH.sub.2, NH(C.sub.1-3 alkyl), N(C.sub.1-3 alkyl).sub.2, C(.dbd.NH)NH.sub.2, CH.sub.2NH.sub.2, CH.sub.2NH(C.sub.1-3 alkyl), CH.sub.2N(C.sub.1-3 alkyl).sub.2, (CR.sup.8R.sup.9).sub.tNR.sup.7R.sup.8, C(O)NR.sup.7.sup.8, CH.sub.2C(O)NR.sup.7R.sup.8, S(O).sub.pNR.sup.7R.sup.8, CH.sub.2S(O).sub.pNR.sup.7R.sup.8, SO.sub.2R.sup.3, and OCF.sub.3; alternatively, when 2 R groups are attached to adjacent atoms, they combine to form methylenedioxy or ethylenedioxy; A is selected from: C.sub.5-10 carbocycle substituted with 0-2 R.sup.4; R.sup.1a, is selected from H, --(CH.sub.2).sub.r--R.sup.1b, --(CH(CH.sub.3)).sub.r--R.sup.1b, --(C(CH.sub.3).sub.2).sub.r--R.sup.1b, NHCH.sub.2R.sup.1c, OCH.sub.2R.sup.1c, SCH.sub.2R.sup.1c, NH(CH.sub.2).sub.2(CH.sub.2).sub.tR.sup.1b, and O(CH.sub.2).sub.2(CH.sub.2).sub.tR.sup.1b, provided that R.sup.1a forms other than an N-halo, N--S, or C--CN bond; alternatively, when two R.sup.1a groups are attached to adjacent atoms, together with the atoms to which they are attached they form a 5-7 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, this ring being substituted with 0-2 R.sup.4band 0-3 ring double bonds; R.sup.1b is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, F, Cl, Br, I, --CN, --CHO, CF.sub.3, OR.sup.2, NR.sup.2R.sup.2a, C(O)R.sup.2b, CO.sub.2R.sup.2b, OC(O)R.sup.2, CO.sub.2R.sup.2a, S(O).sub.pR.sup.2, NR.sup.2(CH.sub.2).sub.rOR.sup.2, NR.sup.2C(O)R.sup.2b, NR.sup.2C(O)NHR.sup.2, NR.sup.2C(O).sub.2R.sup.2a, OC(O)NR.sup.2R.sup.2a, C(O)NR.sup.2R.sup.2a, C(O)NR.sup.2(CH.sub.2).sub.rOR.sup.2, SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2R.sup.2, C.sub.5-6 carbocycle substituted with 0-2 R.sup.4b, and 5-6 membered heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b, provided that R.sup.1b forms other than an O--O, N-halo, N--S, or C--CN bond; R.sup.1c is selected from H, CH(CH.sub.2OR.sup.2).sub.2, C(O)R.sup.2c, C(O)NR.sup.2R.sup.2a, S(O)R.sup.2, S(O).sub.2R.sup.2, and SO.sub.2NR.sup.2R.sup.2a; R.sup.2, at each occurrence, is selected from H, CF.sub.3, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, C.sub.5-6 carbocycle substituted with 0-2 R.sup.4b, a C.sub.5-6 carbocyclic-CH.sub.2-group substituted with 0-2 R.sup.4b, and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.2a, at each occurrence, is selected from H, CF.sub.3, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, C.sub.5-6 carbocycle substituted with 0-2 R.sup.4b, and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; alternatively, R.sup.2 and R.sup.2a, together with the atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-2 R.sup.4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.2b, at each occurrence, is selected from CF.sub.3, C.sub.1-4 alkoxy, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, C.sub.5-6 carbocycle substituted with 0-2 R.sup.4b, and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.2c, at each occurrence, is selected from CF.sub.3, OH, C.sub.1-4 alkoxy, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3; benzyl, C.sub.5-6 carbocycle substituted with 0-2 R.sup.4b, and 5-6 membered heterocycle containing from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sub.3, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, and phenyl; R.sup.3a, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, and phenyl; alternatively, R.sup.3 and R.sup.3a, together with the nitrogen atom to which they are attached, combine to form a 5 or 6 membered saturated, partially unsaturated, or unsaturated ring consisting of: carbon atoms and the nitrogen atom to which R.sup.3 and R.sup.3a are attached; R.sup.3c, at each occurrence, is selected from CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, and phenyl; R.sup.3d, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2-phenyl, CH.sub.2CH.sub.2-phenyl, and C(.dbd.O)R.sup.3c; R.sup.4, at each occurrence, is selected from H, .dbd.O, OR.sup.2, CH.sub.2OR.sup.2, (CH.sub.2).sub.2OR.sup.2, F, Cl, Br, I, C.sub.1-4 alkyl, --CN, NO.sub.2, NR.sup.2R.sup.2a, CH.sub.2NR.sup.2R.sup.2a, (CH.sub.2).sub.2NR.sup.2R.sup.2a, C(O)R.sup.2c, NR.sup.2C(O)R.sup.2b, C(O)NR.sup.2R.sup.2a, SO.sub.2NR.sup.2R.sup.2a, S(O).sub.pR.sup.5a, CF.sub.3, CF.sub.2CF.sub.3, 5-6 membered carbocycle substituted with 0-1 R.sup.5, and a 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5; R.sup.4a, at each occurrence, is selected from H, .dbd.O, CH.sub.2OR.sup.2, OR.sup.2, CH.sub.2F, F, CH.sub.2Br, Br, CH.sub.2Cl, Cl, C.sub.1-4 alkyl, CH.sub.2--CN, --CN, CH.sub.2NO.sub.2, NO.sub.2, CH.sub.2NR.sup.2R.sup.2a, NR.sup.2R.sup.2a, CH.sub.2--C(O)R.sup.2c, C(O)R.sup.2c, NR.sup.2C(O)R.sup.2b, (CH.sub.2).sub.rC(O)NR.sup.2R.sup.2a, NR.sup.2C(O)NR.sup.2R.sup.2a, (CH.sub.2).sub.rSO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2--C.sub.1-4 alkyl, NR.sup.2SO.sub.2R.sup.5, (CH.sub.2).sub.rS(O).sub.pR.sup.5a, CH.sub.2CF.sub.3, CF.sub.3, CH.sub.2-5-6 membered carbocycle substituted with 0-1 R.sup.5, 5-6 membered carbocycle substituted with 0-1 R.sup.5, and a CH.sub.2-5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5, and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5; R.sup.4b, at each occurrence, is selected from H, .dbd.O, OR.sup.3, CH.sub.2OR.sup.3, F, Cl, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, --CN, NO.sub.2, NR.sup.3R.sup.3a, CH.sub.2NR.sup.3R.sup.3a, C(O)R.sup.3, CH.sub.2--C(O)R.sup.3, C(O)OR.sup.3c, CH.sub.2C(O)OR.sup.3c, NR.sup.3C(O)R.sup.3a, CH.sub.2NR.sup.3C(O)R.sup.3a, C(O)NR.sup.3R.sup.3a, CH.sub.2C(O)NR.sup.3R.sup.3a, NR.sup.3C(O)NR.sup.3R.sup.3a, CH.sub.2NR.sup.3C(O)NR.sup.3R.sup.3a, C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, CH.sub.2C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, NR.sup.3C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, CH.sub.2NR.sup.3C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, SO.sub.2NR.sup.3R.sup.3a, CH.sub.2SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2NR.sup.3R.sup.3a, CH.sub.2NR.sup.3SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2--C.sub.1-4 alkyl, CH.sub.2NR.sup.3SO.sub.2--C.sub.1-4 alkyl, NR.sup.3SO.sub.2CF.sub.3, CH.sub.2NR.sup.3SO.sub.2CF.sub.3, NR.sup.3SO.sub.2-phenyl, CH.sub.2NR.sup.3SO.sub.2-phenyl, S(O).sub.pCF.sub.3, CH.sub.2S(O).sub.pCF.sub.3, S(O).sub.p--C.sub.1-4 alkyl, CH.sub.2S(O).sub.p--C.sub.1-4 alkyl, S(O).sub.p-phenyl, CH.sub.2S(O).sub.p-phenyl, CF.sub.3, and CH.sub.2--CF.sub.3; R.sup.4c, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, CH.sub.2OR.sup.2,CH.sub.2F, CH.sub.2Br, CH.sub.2Cl, CH.sub.2CN, CH.sub.2NO.sub.2, CH.sub.2NR.sup.2R.sup.2a, C(O)R.sup.2c, CH.sub.2C(O)R.sup.2c, CH.sub.2NR.sup.2C(O)R.sup.2b, C(O)NR.sup.2R.sup.2a, CH.sub.2C(O)NR.sup.2R.sup.2a, CH.sub.2NR.sup.2C(O)NR.sup.2R.sup.2a, SO.sub.2NR.sup.2R.sup.2a, CH.sub.2SO.sub.2NR.sup.2R.sup.2a, CH.sub.2NR.sup.2SO.sub.2NR.sup.2R.sup.2a, CH.sub.2NR.sup.2SO.sub.2--C.sub.1-4 alkyl, C(O)NHSO.sub.2--C.sub.1-4 alkyl, CH.sub.2C(O)NHSO.sub.2--C.sub.1-4 alkyl, CH.sub.2NR.sup.2SO.sub.2R.sup.5, S(O).sub.pR.sup.5a, CH.sub.2S(O).sub.pR.sup.5a, CF.sub.3, CH.sub.2CF.sub.3, 5-6 membered carbocycle substituted with 0-1 R.sup.5, CH.sub.2-5-6 membered carbocycle substituted with 0-1 R.sup.5, 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5, and a CH.sub.2-5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5; R.sup.5, at each occurrence, is selected from H, .dbd.O, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, OR.sup.3, CH.sub.2OR.sup.3, F, Cl, --CN, NO.sub.2, NR.sup.3R.sup.3a, CH.sub.2NR.sup.3R.sup.3a, C(O)R.sup.3, CH.sub.2C(O)R.sup.3, C(O)OR.sup.3c, CH.sub.2C(O)OR.sup.3c, NR.sup.3C(O)R.sup.3a, C(O)NR.sup.3R.sup.3a, NR.sup.3C(O)NR.sup.3R.sup.3a, CH(.dbd.NOR.sup.3d), C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, NR.sup.3C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2--C.sub.1-4 alkyl, NR.sup.3SO.sub.2CF.sub.3, NR.sup.3SO.sub.2-phenyl, S(O).sub.pCF.sub.3, S(O).sub.p--C.sub.1-4 alkyl, S(O).sub.p-phenyl, CF.sub.3, phenyl substituted with 0-2 R.sup.6, naphthyl substituted with 0-2 R.sup.6, and benzyl substituted with 0-2 R.sup.6; and R.sup.6, at each occurrence, is selected from H, OH, OR.sup.2, F, Cl, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, CN, NO.sub.2, NR.sup.2R.sup.2a, CH.sub.2NR.sup.2R.sup.2a, C(O)R.sup.2b, CH.sub.2C(O)R.sup.2b, NR.sup.2C(O)R.sup.2b, NR.sup.2C(O)NR.sup.2R.sup.2a, C(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2NR.sup.2R.sup.2a, and NR.sup.2SO.sub.2C.sub.1-4 alkyl.

3. A compound according to claim 2, wherein: G is selected from the group: ##STR00244## ##STR00245## ##STR00246## ##STR00247## ##STR00248## ##STR00249## ##STR00250## ##STR00251## ##STR00252## ##STR00253## ##STR00254## G.sub.1 is absent or is selected from (CR.sup.3R.sup.3a).sub.1-3, (CR.sup.3R.sup.3a).sub.uC(O)(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uO(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uNR.sup.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uC(O)NR.sup.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uNR.sup.3bC(O)(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uNR.sup.3bC(O)(CR.sup.3R.sup.3a).sub.uC(O)NR.sup.3- b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uS(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uS(O)(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uS(O).sub.2(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uS(O)NR.sup.3b(CR.sup.3R.sup.3a).sub.w, (CR.sup.3R.sup.3a).sub.uNR.sup.3bS(O).sub.2(CR.sup.3R.sup.3a).sub.w, and (CR.sup.3R.sup.3a).sub.uS(O).sub.2NR.sup.3b(CR.sup.3R.sup.3a).sub.w, wherein u+w total 0, 1, or 2, provided that G.sub.1 does not form a N--S, NCH.sub.2N, NCH.sub.2O, or NCH.sub.2S bond with either group to which it is attached; A is phenyl substituted with 0-2 R.sup.4; R.sup.1a is selected from H, R.sup.1b, CH(CH.sub.3)R.sup.1b, C(CH.sub.3).sub.2R.sup.1b, CH.sub.2R.sup.1b, and CH.sub.2CH.sub.2R.sup.1b, provided that R.sup.1a forms other than an N-halo, N--S, or C--CN bond; alternatively, when two R.sup.1a groups are attached to adjacent atoms, together with the atoms to which they are attached they form a 5-6 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, this ring being substituted with 0-2 R.sup.4b and 0-3 ring double bonds; R.sup.1b is selected from H, CH.sub.3, CH.sub.2CH.sub.3, F, Cl, Br, --CN, --CHO, CF.sub.3, OR.sup.2, NR.sup.2R.sup.2a, C(O)R.sup.2b, CO.sub.2R.sup.2b, OC(O)R.sup.2, CO.sub.2R.sup.2a, S(O).sub.pR.sup.2, NR.sup.2(CH.sub.2).sub.rOR.sup.2, NR.sup.2C(O)R.sup.2b, C(O)NR.sup.2R.sup.2a, SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2R.sup.2, phenyl substituted with 0-2 R.sup.4b, and 5-6 membered aromatic heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b, provided that R.sup.1b forms other than an O--O, N-halo, N--S, or N--CN bond; R.sup.2, at each occurrence, is selected from H, CF.sub.3, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, phenyl substituted with 0-2 R.sup.4b, a benzyl substituted with 0-2 R.sup.4b, and a 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.2a, at each occurrence, is selected from H, CF.sub.3, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, phenyl substituted with 0-2 R.sup.4b, and 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; alternatively, R.sup.2 and R.sup.2a, together with the atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-2 R.sup.4b and consisting of: 0-1additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.2b, at each occurrence, is selected from CF.sub.3, C.sub.1-4 alkoxy, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, phenyl substituted with 0-2 R.sup.4b, and 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.2c, at each occurrence, is selected from CF.sub.3, OH, OCH.sub.3, OCH.sub.2CH.sub.3, OCH.sub.2CH.sub.2CH.sub.3, OCH(CH.sub.3).sub.2, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, phenyl substituted with 0-2 R.sup.4b, and 5-6 membered aromatic heterocycle containing from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.4, at each occurrence, is selected from H, CH.sub.2OR.sup.2, (CH.sub.2).sub.2OR.sup.2, OR.sup.2, F, Cl, Br, I, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, --CN, NO.sub.2, NR.sup.2R.sup.2a, CH.sub.2NR.sup.2R.sup.2a, (CH.sub.2).sub.2NR.sup.2R.sup.2a, C(O)R.sup.2c, NR.sup.2C(O)R.sup.2b, C(O)NR.sup.2R.sup.2a, SO.sub.2NR.sup.2R.sup.2a, CF.sub.3, and CF.sub.2CF.sub.3; R.sup.4a, at each occurrence, is selected from H, .dbd.O, CH.sub.2OR.sup.2, OR.sup.2, F, Br, Cl, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, --CN, NO.sub.2, CH.sub.2NR.sup.2R.sup.2a, NR.sup.2R.sup.2a, C(O)R.sup.2c, NR.sup.2C(O)R.sup.2b, C(O)NR.sup.2R.sup.2a, NR.sup.2C(O)NR.sup.2R.sup.2a, SO.sub.2NR.sup.2R.sup.2a, and --CF.sub.3; R.sup.4b, at each occurrence, is selected from H, .dbd.O, OR.sup.3, CH.sub.2OR.sup.3, F, Cl, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, --CN, NO.sub.2, NR.sup.3R.sup.3a, CH.sub.2NR.sup.3R.sup.3a, C(O)R.sup.3,CH.sub.2--C(O)R.sup.3, C(O)OR.sup.3c, CH.sub.2--C(O)OR.sup.3c, NR.sup.3C(O)R.sup.3a, CH.sub.2NR.sup.3C(O)R.sup.3a, C(O)NR.sup.3R.sup.3a, CH.sub.2--C(O)NR.sup.3R.sup.3a, SO.sub.2NR.sup.3R.sup.3a, CH.sub.2SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2--C.sub.1-4 alkyl, CH.sub.2NR.sup.3SO.sub.2--C.sub.1-4 akyl, CH.sub.2NR.sup.3SO.sub.2-phenyl, CH.sub.2NR.sup.3SO.sub.2-phenyl, S(O).sub.pCF.sub.3, CH.sub.2S(O).sub.pCF.sub.3, S(O).sub.p--C.sub.1-4 alkyl, CH.sub.2S(O).sub.p--C.sub.1-4 alkyl, S(O).sub.p-phenyl, CH.sub.2S(O).sub.p-phenyl, and CF.sub.3; R.sup.4c, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, CH.sub.2OR.sup.2, CH.sub.2F, CH.sub.2Br, CH.sub.2Cl, CH.sub.2CN, CH.sub.2NO.sub.2, CH.sub.2NR.sup.2R.sup.2a, C(O)R.sup.2c, CH.sub.2C(O)R.sup.2c, CH.sub.2NR.sup.2C(O)R.sup.2b, C(O)NR.sup.2R.sup.2a, CH.sub.2C(O)NR.sup.2R.sup.2a, SO.sub.2NR.sup.2R.sup.2a, CH.sub.2SO.sub.2NR.sup.2R.sup.2a, S(O).sub.pR.sup.5a, CH.sub.2S(O).sub.pR.sup.5a,CF.sub.3, phenyl substituted with 0-1 R.sup.5, and benzyl substituted with 0-1 R.sup.5; R.sup.5, at each occurrence, is selected from H, .dbd.O, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, OR.sup.3, CH.sub.2OR.sup.3, F, Cl, --CN, NO.sub.2, NR.sup.3R.sup.3a, CH.sub.2NR.sup.3R.sup.3a, C(O)R.sup.3, CH.sub.2C(O)R.sup.3, C(O)OR.sup.3c, CH.sub.2C(O)OR.sup.3c, NR.sup.3C(O)R.sup.3a, C(O)NR.sup.3R.sup.3a, SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2--C.sub.1-4 alkyl, NR.sup.3SO.sub.2CF.sub.3, NR.sup.3SO.sub.2-phenyl, S(O).sub.pCF.sub.3, S(O).sub.p--C.sub.1-4 alkyl, S(O).sub.p-phenyl, CF.sub.3, phenyl substituted with 0-2 R.sup.6, naphthyl substituted with 0-2 R.sup.6, and benzyl substituted with 0-2 R.sup.6; and R.sup.6, at each occurrence, is selected from H, OH, OR.sup.2, F, Cl, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, --CN, NO.sub.2, NR.sup.2R.sup.2a, CH.sub.2NR.sup.2R.sup.2a, C(O)R.sup.2b, CH.sub.2C(O)R.sup.2b, NR.sup.2C(O)R.sup.2b, SO.sub.2NR.sup.2R.sup.2a, and NR.sup.2SO.sub.2C.sub.1-4 alkyl.

4. A compound according to claim 3, wherein: G is selected from the group: ##STR00255## ##STR00256## ##STR00257## ##STR00258## ##STR00259## ##STR00260## G.sub.1 is absent or is selected from CH.sub.2, CH.sub.2CH.sub.2, CH.sub.2O, OCH.sub.2, NH, CH.sub.2NH, NHCH.sub.2, CH.sub.2C(O), C(O)CH.sub.2, C(O)NH, NHC(O), CH.sub.2S(O).sub.2, S(O).sub.2(CH.sub.2), SO.sub.2NH, and NHSO.sub.2, provided that G.sub.1 does not form a N--S, NCH.sub.2N, NCH.sub.2O, or NCH.sub.2S bond with either group to which it is attached; R.sup.1a is selected from H, R.sup.1b, C(CH.sub.3).sub.2R.sup.1b, and CH.sub.2R.sup.1b, provided that R.sup.1a, forms other than an N-halo, N--S, or C--CN bond; R.sup.1bis selected from CH.sub.3, CH.sub.2CH.sub.3, F, Cl, Br, --CN, CF.sub.3, OR.sup.2, NR.sup.2R.sup.2a, C(O)R.sup.2b, CO.sub.2R.sup.2b, CO.sub.2R.sup.2a, S(O).sub.pR.sup.2, C(O)NR.sup.2R.sup.2a, SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2R.sup.2, and 5-6 membered aromatic heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b, provided that R.sup.1bforms other than an O--O, N-halo, N--S, or C--CN bond; R.sup.2, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, phenyl substituted with 0-1 R.sup.4b, benzyl substituted with 0-1 R.sup.4b, and 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.4b; R.sup.2a, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, phenyl substituted with 0-1 R.sup.4b, and 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.4b; alternatively, R.sup.2 and R.sup.2a, together with the atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-1 R.sup.4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.2b, at each occurrence, is selected from OCH.sub.3, OCH.sub.2CH.sub.3, OCH.sub.2CH.sub.2CH.sub.3, OCH(CH.sub.3).sub.2, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, phenyl substituted with 0-1 R.sup.4b, and 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.4b; R.sup.2c, at each occurrence, is selected from OH, OCH.sub.3, OCH.sub.2CH.sub.3, OCH.sub.2CH.sub.2CH.sub.3, OCH(CH.sub.3).sub.2, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, phenyl substituted with 0-1 R.sup.4b, and 5-6 membered aromatic heterocycle containing from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.4b; R.sup.4, at each occurrence, is selected from OH, OR.sup.2, CH.sub.2OR.sup.2, (CH.sub.2).sub.2OR.sup.2, F, Br, Cl, I, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, NR.sup.2R.sup.2a, CH.sub.2NR.sup.2R.sup.2a, (CH.sub.2).sub.2NR.sup.2R.sup.2a, CF.sub.3, and CF.sub.2CF.sub.3; R.sup.4a, at each occurrence, is selected from H, .dbd.O, CH.sub.2OR.sup.2, OR.sup.2, F, Br, Cl, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, CH.sub.2NR.sup.2R.sup.2a, NR.sup.2R.sup.2a, C(O)R.sup.2c, NR.sup.2C(O)R.sup.2b, C(O)NR.sup.2R.sup.2a, SO.sub.2NR.sup.2R.sup.2a, and CF.sub.3; R.sup.4b, at each occurrence, is selected from H, .dbd.O, OR.sup.3, CH.sub.2OR.sup.3, F, Cl, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, --CN, NO.sub.2, NR.sup.3R.sup.3a, CH.sub.2NR.sup.3R.sup.3a, C(O)R.sup.3, C(O)OR.sup.3c, NR.sup.3C(O)R.sup.3a, C(O)NR.sup.3R.sup.3a, SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2--C.sub.1-4 alkyl, NR.sup.3SO.sub.2-phenyl, S(O).sub.p--C.sub.1-4 alkyl, S(O).sub.p-phenyl, and CF.sub.3; R.sup.4c, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, phenyl substituted with 0-1 R.sup.5, and benzyl substituted with 0-1 R.sup.5; R.sup.5, at each occurrence, is selected from H, .dbd.O, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, OR.sup.3, CH.sub.2OR.sup.3, F, Cl, --CN, NO.sub.2, NR.sup.3R.sup.3a, CH.sub.2NR.sup.3R.sup.3a, C(O)R.sup.3, C(O)OR.sup.3c, NR.sup.3C(O)R.sup.3a, C(O)NR.sup.3R.sup.3a, SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2--C.sub.1-4 alkyl, NR.sup.3SO.sub.2-phenyl, S(O).sub.p--C.sub.1-4 alkyl, S(O).sub.p-phenyl, CF.sub.3, phenyl substituted with 0-2 R.sup.6, naphthyl substituted with 0-2 R.sup.6, and benzyl substituted with 0-2 R.sup.6; and R.sup.6, at each occurrence, is selected from H, OH, OR.sup.2, F, Cl, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, --CN, NO.sub.2, NR.sup.2R.sup.2a, CH.sub.2NR.sup.2R.sup.2a, C(O)R.sup.2b, CH.sub.2C(O)R.sup.2b, NR.sup.2C(O)R.sup.2b, and SO.sub.2NR.sup.2R.sup.2a.

5. A compound according to claim 4, wherein: G is selected from: ##STR00261## ##STR00262## ##STR00263## ##STR00264## A is selected from the group: phenyl, 2-Cl-phenyl, 3-Cl-phenyl, 2-F-phenyl, 3-F-phenyl, 2-methyiphenyl, 2-aminophenyl, and 2-methoxyphenyl; B is attached to a different atom on A than M and is selected from the group: ##STR00265## R.sup.1a is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH.sub.2F, CH.sub.2Cl, Br, CH.sub.2Br, --CN, CH.sub.2CN, CF.sub.3, CH.sub.2CF.sub.3, OCH.sub.3, CH.sub.2OH, C(CH.sub.3).sub.2OH, CH.sub.2OCH.sub.3, NH.sub.2, CH.sub.2NH.sub.2, NHCH.sub.3, CH.sub.2NHCH.sub.3, N(CH.sub.3).sub.2, CH.sub.2N(CH.sub.3).sub.2, CO.sub.2H, COCH.sub.3, CO.sub.2CH.sub.3, CH.sub.2CO.sub.2CH.sub.3, SCH.sub.3, CH.sub.2SCH.sub.3, S(O)CH.sub.3, CH.sub.2S(O)CH.sub.3, S(O).sub.2CH.sub.3, CH.sub.2S(O).sub.2CH.sub.3, C(O)NH.sub.2, CH.sub.2C(O)NH.sub.2, SO.sub.2NH.sub.2, CH.sub.2SO.sub.2NH.sub.2, NHSO.sub.2CH.sub.3, CH.sub.2NHSO.sub.2CH.sub.3, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridin-2-yl-N-oxide, pyridin-3-yl-N-oxide, pyridin-4-yl-N-oxide, imidazol-1-yl, CH.sub.2-imidazol-1-yl, 4-methyl-oxazol-2-yl, 4-N,N-dimethylaminomethyl-oxazol-2-yl, 1,2,3,4-tetrazol-1-yl, 1,2,3,4-tetrazol-5-yl, CH.sub.2-1,2,3,4-tetrazol-1-yl, and CH.sub.2-1,2,3,4-tetrazol-5-yl; R.sup.2, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, phenyl substituted with 0-1 R.sup.4b, benzyl substituted with 0-1 R.sup.4b, and 5 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.4b; R.sup.2a, at each occurrence, is selected from H, CH.sub.3, and CH.sub.2CH.sub.3; alternatively, R.sup.2 and R.sup.2a, together with the atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-1 R.sup.4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.2b, at each occurrence, is selected from OCH.sub.3, OCH.sub.2CH.sub.3, CH.sub.3, and CH.sub.2CH.sub.3; R.sup.2c, at each occurrence, is selected from OH, OCH.sub.3, OCH.sub.2CH.sub.3, CH.sub.3, and CH.sub.2CH.sub.3; R.sup.4a, at each occurrence, is selected from H, .dbd.O, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, and C(CH.sub.3).sub.3; R.sup.4b, at each occurrence, is selected from H, .dbd.O, OR.sup.3, CH.sub.2OR.sup.3, F, Cl, CH.sub.3, CH.sub.2CH.sub.3, NR.sup.3R.sup.3a, CH.sub.2NR.sup.3R.sup.3a, C(O)R.sup.3, C(O)OR.sup.3c, NR.sup.3C(O)R.sup.3a, C(O)NR.sup.3R.sup.3a, SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2-phenyl, S(O).sub.2CH.sub.3, S(O).sub.2-phenyl, and CF.sub.3; R.sup.5, at each occurrence, is selected from H, .dbd.O, CH.sub.3, CH.sub.2CH.sub.3, OR.sup.3, CH.sub.2OR.sup.3, F, Cl, NR.sup.3R.sup.3a, CH.sub.2NR.sup.3R.sup.3a, C(O)R.sup.3, C(O)OR.sup.3c, NR.sup.3C(O)R.sup.3a, C(O)NR.sup.3R.sup.3a, SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2--C.sub.1-4 alkyl, NR.sup.3 SO.sub.2-phenyl, S(O).sub.2--CH.sub.3, S(O).sub.2-phenyl, CF.sub.3, phenyl substituted with 0-2 R.sup.6, naphthyl substituted with 0-2 R.sup.6, and benzyl substituted with 0-2 R.sup.6; and R.sup.6, at each occurrence, is selected from H, OH, OR.sup.2, F, Cl, CH.sub.3, CH.sub.2CH.sub.3, NR.sup.2R.sup.2a, CH.sub.2NR.sup.2R.sup.2a, C(O)R.sup.2b, CH.sub.2C(O)R.sup.2b, NR.sup.2C(O)R.sup.2b, and SO.sub.2NR.sup.2R.sup.2a.

6. A compound according to claim 5, wherein the compound is P.sub.4 is --G; G is selected from: ##STR00266## ##STR00267## A-B is selected from: ##STR00268##

7. A compound according to claim 6, wherein: A-B is ##STR00269##

8. A compound according to claim 1, wherein the compound is selected from the group: 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-4,5,6,7-tet- rahydro-1H-pyrazolo [3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-(4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-(2-pyridinyl)-1- ,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(3-chlorophenyl)-7-oxo-6-[4-(2-oxo-1(2H)pyridinyl)phenyl]-4,5,6,7-tetra- hydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-4,5,6,7-tet- rahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(2,3-dihydro-1H-indol-6-yl)-6-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-(trif- luoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(2,3-dihydro-1H-isoindol-5-yl)-6-[4-(2-oxo-2H-pyridin-1-yl)phenyl]-3-tr- ifluoromethyl-1,4,5,6-tetrahydropyrazolo[3,4-c]pyridin-7-one; ethyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-4,5,6,7-tet- rahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate; 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-4,5,6,7-tet- rahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid; 1-(4-methoxyphenyl)-N,N-dimethyl-7-oxo-6-[4-(2-oxo-1(2H)-pyridinyl)phenyl- ]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; N-({1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-4,5,6,7- -tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-yl}carbonyl)methanesulfonamide; 1-(4-methoxyphenyl)-6-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-( 1H-tetrazol-5-yl)-1,4,5,6, -tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 3-{4-[dimethylamino)methyl]-1,3-oxazol-2-yl}1-1-(4-methoxyphenyl)-6-[4-(2- -oxo-1(2H)-pyridinyl)phenyl]-1,4,5,6, -tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-3-(4-methyl-oxazol-2-yl)-6-[4-(2-oxo-2H-pyridin-1-yl- )-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-acetyl-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,- 6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-(4,5-dihydro-1H-imidazol-2-yl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyri- din-1-yl)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-hydroxymethyl-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]- -1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-( 1-hydroxy-1-methyl-ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-y- l)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 2-dimethylamino-N-{1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-2H-pyridin-1-yl)- -phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-ylmethyl}acetamide- ; N-hydroxy-3-{7-oxo-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3-trifluoromethy- l-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl}-benzamidine; N-methoxy-3-{7-oxo-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3-trifluoromethyl- -4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl}-benzamidine; 2-{7-oxo-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3-trifluoromethyl-4,5,6,7-t- etrahydro-pyrazolo[3,4-c]pyridin-1-yl}-benzenesulfonamide; N-acetyl-2-{7-oxo-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3-trifluoromethyl-- 4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl}-benzenesulfonamide; 1-(3-chloro-phenyl)-3-methanesulfonyl-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl- ]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-3-methyl-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,- 6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(3-chloro-phenyl)-3-(1-hydroxy-1-methyl-ethyl)-6-[4-(2-oxo-2H-pyridin-1- -yl)-phenyl]-1,4,5,6-tetrahydropyrazolo[3,4-c]pyridin-7-one; and 3-{7-oxo-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3-trifluoromethyl-4,5,6,7-t- etrahydro-pyrazolo[3,4-c]pyridin-1-yl}-benzamide; or a pharmaceutically acceptable salt form thereof.

9. A compound is 1-(3-chlorophenyl)-7-oxo-6-[4-(2-oxo-1(2H)pyridinyl)phenyl]-4,5,6,7-tetra- hydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide.

10. A compound is 3-(1-hydroxy-1-methyl-ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-- 1-yl)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one.

11. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1.

12. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 7.

13. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 9.

14. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 10.

15. A method for treating a thromboembolic disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1.

16. A method for treating a thromboembolic disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of a compound of claim 7.

17. A method for treating a thromboembolic disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of a compound of claim 9.

18. A method for treating a thromboembolic disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of a compound of claim 10.

19. A method according to claim 15, wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart.

20. A method according to claim 19, wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recuffent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, or (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis.

21. A method according to claim 16, wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart.

22. A method according to claim 21, wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, or (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis.

23. A method according to claim 17, wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart.

24. A method according to claim 23, wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, or (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis.

25. A method according to claim 18, wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart.

26. A method according to claim 25, wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, or (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis.
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