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|Title:||Quinuclidine derivatives and medicinal compositions containing the same|
|Abstract:||The invention provides 1-phenethyl-3 (R)-(9[H]-xanthene-9-carbonyloxy)-1 -azoniabicyclo[2.2.2]octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders.|
|Inventor(s):||Fernandez Forner; Maria Dolors (Barcelona, ES), Prat Quinones; Maria (Barcelona, ES), Buil Albero; Maria Antonia (Barcelona, ES)|
|Assignee:||Laboratories Almirall, S.A. (Barcelona, ES)|
|Filing Date:||Dec 08, 2006|
|Claims:||1. A compound which is 3(R)-1-phenethyl-(9[H]-xanthene-9-carbonyloxy)-1-azoniabicyclo[2.2.2] octane wherein an anion X.sup.- is associated with the positive charge of the nitrogen atom and wherein X.sup.- is a pharmaceutically acceptable anion of a mono- or polyvalent acid. |
2. The compound according to claim 1 which is 3(R)-1-phenethyl-(9[H]-xanthene-9-carbonyloxy)-1-azoniabicyclo[2.2.2]octa- ne bromide.
3. A pharmaceutical composition comprising a compound according to claim 1 in admixture with a pharmaceutically acceptable carrier or diluent.
4. The pharmaceutical composition of claim 3 comprising 3(R)-1-phenethyl-(9[H]-xanthene-9-carbonyloxy)-1-azoniabicyclo[2.2.2]octa- ne bromide.
5. A method for treating chronic obstructive pulmonary disease, chronic bronchitis, bronchial hyperreactivity, asthma, or rhinitis which method comprises administering to a human or animal patient in need of such treatment an effective amount of a compound according to claim 1.
6. The method according to claim 5 comprising administering to the patient an effective amount 3(R)-1-phenethyl-(9[H]-xanthene-9-carbonyloxy)-1-azoniabicyclo[2.2.2]octa- ne bromide.
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