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|Title:||Composition comprising low density microspheres|
|Abstract:||Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.|
|Inventor(s):||Unger; Evan C. (Tucson, AZ)|
|Assignee:||Bristol-Myers Squibb Medical Imaging, Inc. (Princeton, NJ)|
|Filing Date:||Oct 18, 2005|
|Claims:||1. A composition comprising low density microspheres, said microspheres comprising a polymer and having a void containing the vapor of a volatile liquid perfluorocarbon, wherein said microspheres, when combined with an aqueous solution to form a contrast agent, are suitable for administration to a patient either orally, rectally or by injection, and further wherein said microspheres have an internal void volume which is at least about 75% of the total volume of said microspheres. |
2. The composition of claim 1, wherein said microspheres have a void volume of at least about 80% of the total volume of said microspheres.
3. The composition of claim 1, wherein said microspheres have a void volume of at least about 85% of the total volume of said microspheres.
4. The composition of claim 1, wherein said microspheres have a void volume of at least about 90% of the total volume of said microspheres.
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