.

BioPharmaceutical Business Intelligence

  • Analyze global market entry opportunities
  • Identify first generic entrants
  • Uncover prior art in expired and abandoned patents

► See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Fuji
US Department of Justice
Farmers Insurance
Citi
Chinese Patent Office
Teva
Novartis
Fish and Richardson
QuintilesIMS
US Army

Generated: July 28, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title:Compositions and methods for treating cancer
Abstract: This invention provides compositions and methods for treating neoplasias in a mammal. In particular, the invention provides liposome-encapsulated vinca alkaloids, e.g., vinorelbine, and methods of treating a mammal using such compositions.
Inventor(s): Sarris; Andreas H (Houston, TX), Cabanillas; Fernando (Houston, TX), Logan; Patricia M (Vancouver, CA), Burge; Clive T R (Brentwood Bay, CA), Goldie; James H (Vancouver, CA), Webb; Murray S (Delta, CA), Madden; Thomas D (Vancouver, CA), Semple; Sean C (Vancouver, CA), Ahkong; Quet F (Surrey, CA), Klimuk; Sandra K (Vancouver, CA)
Assignee: Hana Biosciences, Inc. (South San Francisco, CA)
Filing Date:Apr 03, 2003
Application Number:10/407,864
Claims:1. A method of treating a solid tumor in a mammal, comprising administering to said mammal a pharmaceutical composition comprising liposome-encapsulated vinorelbine, wherein the said solid tumor is selected from the group consisting of lung cancer, breast cancer, colon cancer, prostate cancer and renal cancer.

2. The method of claim 1, wherein the pharmaceutical composition is administered to said mammal every seven days.

3. The method of claim 2, wherein said pharmaceutical composition is administered to said mammal for at least three weeks.

4. The method of claim 2, wherein the therapeutic index of the pharmaceutical composition is greater than the therapeutic index of free vinorelbine.

5. The method of claim 4, wherein the therapeutic index of the pharmaceutical composition is at least 1.4-fold greater than the therapeutic index of free vinorelbine.

6. The method of claim 4, wherein the therapeutic index of the pharmaceutical composition is at least 2-fold greater than the therapeutic index of free vinorelbine.

7. The method of claim 4, wherein the therapeutic index of the pharmaceutical composition is at least 2.4-fold greater than the therapeutic index of free vinorelbine.

8. The method of claim 4, wherein the therapeutic index of the pharmaceutical composition is at least 3.6-fold greater than the therapeutic index of free vinorelbine.

9. The method of claim 1, wherein the liposome comprises sphingomyelin and cholesterol.

10. The method of claim 9, wherein the ratio of sphingomyelin to cholesterol is between 75/25 and 50/50 (mol % sphingomyelin/mol % cholesterol).

11. The method of claim 10, wherein the ration of sphingomyelin to cholesterol is approximately 55:45 (mol % sphingomyelin/mol % cholesterol).

12. The method of claim 1, wherein the ratio of vinorelbine to lipid is 0.001-0.5:1 (w/w).

13. The method of claim 12, wherein the ratio of vinorelbine to lipid is at least 0.1:1 (w/w).

14. The method of claim 13, wherein the ratio of vinorelbine to lipid is 0.1-0.3:1 (w/w).
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Teva
US Department of Justice
Fish and Richardson
Medtronic
McKesson
Accenture
Covington
Argus Health
Cipla
Johnson and Johnson

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot