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Details for Patent: 7,273,614

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Details for Patent: 7,273,614

Title:Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids
Abstract: The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
Inventor(s): Bolognesi; Dani Paul (Durham, NC), Matthews; Thomas James (Durham, NC), Wild; Carl T. (Durham, NC)
Assignee: Duke University (Durham, NC)
Filing Date:Oct 09, 2002
Application Number:10/267,682
Claims:1. An isolated nucleic acid molecule encoding a peptide consisting of the amino acid sequence of DP-178 (SEQ ID NO:1).

2. An isolated nucleic acid molecule encoding a peptide consisting of the amino acid sequence of X-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-Z (SEQ ID NO:1), wherein the peptide amino acid residues are presented by the single-letter code, further wherein: X comprises an amino group, an acetyl group, a 9-fluorenylmethoxy-carbonyl group, a hydrophobic group, or a macromolecule carrier group; and Z comprises a carboxyl group, an amido group, a hydrophobic group, or a macromolecular carrier group.

3. The nucleic acid of claim 2, wherein X is a hydrophobic group.

4. The nucleic acid of claim 3, wherein the hydrophobic group X is carbobenzoxyl, dansyl, or t-butyloxycarbonyl.

5. The nucleic acid of claim 2, wherein Z is a hydrophobic group.

6. The nucleic acid of claim 5, wherein the hydrophobic group Z is t-butyloxycarbonyl.

7. The nucleic acid of claim 2, wherein X is a macromolecular carrier group.

8. The nucleic acid of claim 7, wherein the macromolecular carrier group is a lipid-fatty acid conjugate, a polyethylene glycol, or a carbohydrate moiety.

9. The nucleic acid of claim 2, wherein Z is a macromolecular carrier group.

10. The nucleic acid of claim 9, wherein the macromolecular carrier group Z is a lipid-fatty acid conjugate, a polyethylene glycol, or a carbohydrate moiety.

11. The nucleic acid of claim 2, wherein at least one bond linking adjacent amino acid residues is a non-peptide bond.

12. The nucleic acid of claim 11, wherein the non-peptide bond is an imino, ester, hydrazine, semicarbazide, or azo bond.

13. The nucleic acid of claim 2, wherein at least one amino acid residue is in a D-isomer configuration.

14. The nucleic acid of claim 2, wherein the peptide comprises between one and three amino acid substitutions of a first amino acid residue for a second, different amino acid residue.

15. A recombinant vector comprising the nucleic acid molecule of claim 1.

16. A recombinant vector comprising a nucleic acid molecule encoding a fusion protein comprising DP-178 (SEQ ID NO:1).
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