|Title:||Chloride channel opener|
|Abstract:||Disclosed is a novel use of a prostaglandin compound as a chloride channel opener. According to the instant invention, chloride channels in a mammalian subject can be opened by a prostaglandin compound to facilitate chloride ion transportation.|
|Inventor(s):||Ueno; Ryuji (Montgomery, MD), Cuppoletti; John (Cincinnati, OH)|
|Assignee:||Sucampo AG (Zug, CH)|
|Filing Date:||Jan 18, 2006|
|Claims:||1. A compound represented by formula (IV): ##STR00013## wherein L, M and N are hydrogen, hydroxy, halogen, lower alkyl, hydroxy(lower)alkyl, or oxo, wherein at least one of L and M is a group other than hydrogen, and the five-membered ring may have one or more double bonds; R' and R'' are hydrogen, lower alkyl, aryl, alkyl- or aryl-sulfonyl, lower alkenyl or lower alkynyl; B is --CH.sub.2--CH.sub.2--, --CH.dbd.CH-- or --C.ident.C--; R.sub.1 is a saturated or unsaturated bivalent lower or medium aliphatic hydrocarbon residue, which is unsubstituted or substituted with halogen, alkyl, hydroxy, oxo, or aryloxy, and at least one carbon atom in the aliphatic hydrocarbon is optionally substituted by oxygen, nitrogen or sulfur; and Ra is a saturated or unsaturated lower or medium aliphatic hydrocarbon residue, which is unsubstituted or substituted with halogen, oxo, hydroxy, lower alkoxy, lower alkanoyloxy, cyclo(lower)alkyl, cyclo(lower)alkyloxy, aryl, or aryloxy; cyclo(lower)alkyl; cyclo(lower)alkyloxy; aryl; or aryloxy. |
2. The compound as described in claim 1, wherein said compound is 13,14-dihydro-15-keto-16,16-difluoro-PGE.sub.1 N-ethyl amide.
3. The compound as described in claim 1, wherein said compound is 13,14-dihydro-15-keto-16,16-difluoro-PGF.sub.1.alpha. N-ethyl amide.
4. The compound as described in claim 1, wherein said compound is 13,14-dihydro-15-keto-17-phenyl-18,19,20-trinor-PGF.sub.2.alpha. N-ethyl amide.
5. The compound as described in claim 1, wherein said compound is 13,14-dihydro-15-keto-20-ethyl-PGF.sub.2.alpha. N-ethyl amide.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.