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|Title:||Brain natriuretic peptide|
|Abstract:||Peptides comprising the effective portion of human brain natriuretic peptide are provided in pharmaceutical compositions and methods to effect vasodilation and/or natriuresis.|
|Inventor(s):||Seilhamer; J. Jeffrey (Milpitas, CA), Lewicki; John A. (San Jose, CA), Scarborough; Robert M. (Hayward, CA), Porter; J. Gordon (Newark, CA)|
|Assignee:||Scios, Inc. (Fremont, CA)|
|Filing Date:||Sep 23, 2005|
|Claims:||1. A method to synthesize a peptide of the formula Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-S- er-Ser-Ser-Ser-Gly-Leu-Gly-Cis-Lys-Val-Leu-Arg-Arg-His (SEQ ID NO: 49) or the amide thereof which method comprises sequentially adding amino acids from the carboxy terminal and using an .alpha.-amino protected amino acid using solid phase peptide synthesis.|
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