Details for Patent: 7,173,017
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Title: | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
Abstract: | Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed. |
Inventor(s): | von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD), Hiltbrand; Bradley M. (Columbia, MD) |
Assignee: | Wellstat Therapeutics Corporation (Gaithersburg, MD) |
Filing Date: | Jun 05, 1995 |
Application Number: | 08/465,455 |
Claims: | 1. A method for treating or preventing hepatic damage in an animal receiving parenteral nutrition comprising administering intravenously to said animal a therapeutically effective amount of a pyrimidine nucleotide precursor and including the further step of administering an inhibitor of uridine phosphorylase. 2. A method as in claim 1 wherein said hepatic damage is due to said animal receiving parenteral nutrition. 3. A method as in claim 1 wherein said pyrimidine nucleotide precursor is uridine, cytidine, orotic acid, or an acyl derivative of uridine, cytidine, or orotic acid, or a pharmaceutically acceptable salt thereof. 4. A method as in claim 1 wherein from 2 to 40 grams of said pyrimidine nucleotide precursor are administered per day. 5. A method for treating or preventing hepatic damage in an animal receiving total parenteral nutrition comprising administering to said animal an inhibitor of uridine phosphorylase. |