|Title:||Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis|
|Abstract:|| Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.|
|Inventor(s):|| von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD), Hiltbrand; Bradley M. (Columbia, MD) |
|Assignee:|| Wellstat Therapeutics Corporation (Gaithersburg, MD) |
|Filing Date:||Jun 05, 1995|
|Claims:||1. A method for treating or preventing hepatic damage in an animal receiving parenteral nutrition comprising administering intravenously to said animal a therapeutically effective amount of a pyrimidine nucleotide precursor and including the further step of administering an inhibitor of uridine phosphorylase. |
2. A method as in claim 1 wherein said hepatic damage is due to said animal receiving parenteral nutrition.
3. A method as in claim 1 wherein said pyrimidine nucleotide precursor is uridine, cytidine, orotic acid, or an acyl derivative of uridine, cytidine, or orotic acid, or a pharmaceutically acceptable salt thereof.
4. A method as in claim 1 wherein from 2 to 40 grams of said pyrimidine nucleotide precursor are administered per day.
5. A method for treating or preventing hepatic damage in an animal receiving total parenteral nutrition comprising administering to said animal an inhibitor of uridine phosphorylase.