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Details for Patent: 7,173,017

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Details for Patent: 7,173,017

Title:Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
Abstract: Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
Inventor(s): von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD), Hiltbrand; Bradley M. (Columbia, MD)
Assignee: Wellstat Therapeutics Corporation (Gaithersburg, MD)
Filing Date:Jun 05, 1995
Application Number:08/465,455
Claims:1. A method for treating or preventing hepatic damage in an animal receiving parenteral nutrition comprising administering intravenously to said animal a therapeutically effective amount of a pyrimidine nucleotide precursor and including the further step of administering an inhibitor of uridine phosphorylase.

2. A method as in claim 1 wherein said hepatic damage is due to said animal receiving parenteral nutrition.

3. A method as in claim 1 wherein said pyrimidine nucleotide precursor is uridine, cytidine, orotic acid, or an acyl derivative of uridine, cytidine, or orotic acid, or a pharmaceutically acceptable salt thereof.

4. A method as in claim 1 wherein from 2 to 40 grams of said pyrimidine nucleotide precursor are administered per day.

5. A method for treating or preventing hepatic damage in an animal receiving total parenteral nutrition comprising administering to said animal an inhibitor of uridine phosphorylase.
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