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|Title:||Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides|
|Abstract:||The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.|
|Inventor(s):||von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD)|
|Assignee:||Wellstat Therapeutics Corporation (Gaithersburg, MD)|
|Filing Date:||Jun 07, 1995|
|Claims:||1. A composition comprising an acyl derivative of uridine; and a compound capable of inhibiting uridine phosphorylase. |
2. A composition as in claim 1 wherein said inhibitor of uridine phosphorylase is selected from the group consisting of benzylacyclouridine, benzyloxybenzylacyclo-uridine, aminomethyl-benzylacyclouridine, aminomethyl-benzyloxybenzylacyclouridine, hydroxymethyl-benzylacyclouridine, hydroxymethyl-benzyloxybenzyl-acyclouridine, 2,2'-anhydro-5-ethyluridine, 5-benzyl barbiturate, 5-benzyloxybenzyl barbiturate, 5-benzyloxybenzyl-1-[(1-hydroxy-2-ethoxy)methyl]barbiturate, 5-benzyloxybenzylacetyl-1-[(1-hydroxy-2-ethoxy)methyl]barbiturate, and 5-methoxybenzylacetylacyclobarbiturate.
3. A composition comprising: an acyl derivative of cytidine or deoxycytidine; and a compound capable of inhibiting deoxycytidine deaminase.
4. A composition as in claim 3 wherein said inhibitor of cytidine deaminase is selected from the group consisting of tetrahydrouridine or tetrahydro-2'-deoxyuridine.