Details for Patent: 7,141,593
✉ Email this page to a colleague
Title: | Pharmaceutical formulations |
Abstract: | Improved pharmaceutical compositions are provided comprising one or more solubilized HIV protease inhibiting compounds having improved solubility properties in a medium and/or long chain fatty acid, or mixtures thereof, a pharmaceutically acceptable alcohol, and water. |
Inventor(s): | Alani; Laman (Morris Plains, NJ), Ghosh; Soumojeet (Linderhurst, IL) |
Assignee: | Abbott Laboratories (Abbott Park, IL) |
Filing Date: | May 22, 2000 |
Application Number: | 09/576,097 |
Claims: | 1. A pharmaceutical composition comprising a solution which comprises: (a) (2S,3S,5S)-5-(N-(N-((N-methyl-N-((2-isopropyl-4-thiazolyl)-methyl)ami- no)carbonyl)-L-valinyl)amino)-2-(N-((5thiazolyl)methoxy-carbonyl)-amino)-1- ,6-diphenyl-3-hydroxyhexane (ritonavir) or a combination of ritonavir and another HIV protease inhibiting compound, or pharmaceutically acceptable salts thereof, in an amount of from 1% to 50% by weight of said solution; (b) a pharmaceutically acceptable medium and/or long chain fatty acid, or a mixture of pharmaceutically acceptable medium and/or long chain fatty acids, in an amount of from 30% to 75% by weight of said solution; (c) ethanol or propylene glycol in an amount of from 1% to 15% by weight of said solution; (d) water in an amount of from 0.4% to 3.5% by weight of said solution; and, optionally, (e) a pharmaceutically acceptable surfactant. 2. The composition according to claim 1, wherein said solution comprises ritonavir and said another HIV protease inhibiting compound. 3. The composition according to claim 2, wherein said another HIV protease inhibiting compound is (2S,3 S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropy- rimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane (ABT-378). 4. The composition according to claim 2, wherein said another HIV protease inhibiting compound is a compound selected from the group consisting of: (1) (2S,3S,5 S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrim- id-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane, (2) N-(2(R)-hydroxy-1 (S)-indanyl)-2(R)-phenylmethyl-4(S)-hydroxy-5-(1-(4-(3-pyridylmethyl)-2(S- )-N'-(t-butylcarboxamido)-piperazinyl))-pentaneamide (indinavir), (3) N-tert-butyl-decahydro-2-[2(R)-hydroxy-4-phenyl-3(S)-[[N-(2-quinolylcarbo- nyl)-L-asparaginyl]amino]butyl]-(4aS,8aS)-isoquinoline-3 (S)-carboxamide (saquinavir), (4) 5(S)-Boc-amino-4(S)-hydroxy-6-phenyl-2(R)-phenylmethylhexanoyl-(L)-Val-(L- )-Phe-morpholin-4-ylamide, (5) 1-Naphthoxyacetyl-beta-methylthio-Ala-(2S, 3S)-3-amino-2-hydroxy-4-butanoyl 1,3-thiazolidine-4-t-butylamide, (6) 5-isoquinolinoxyacetyl-beta-methylthio-Ala-(2S,3 S)-3-amino-2-hydroxy-4-butanoyl-1,3-thiazolidine-4-t-butylamide, (7) [1S-[1R-(R-),2S*])--N.sup.1 [3-[[[(1,1-dimethylethyl)amino]carbonyl](2-methylpropyl) amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-- butanediamide, (8) ##STR00011## ##STR00012## or a pharmaceutically acceptable salt thereof. 5. The composition according to claim 1, wherein said surfactant is in an amount of from 2% to 20% by weight of said solution. 6. The composition according to claim 1, wherein said solution comprises ritonavir or a combination of ritonavir and said another HIV protease inhibiting compound, or pharmaceutically acceptable salts thereof, in an amount of from 10 to 40% by weight of said solution. 7. The composition according to claim 1, wherein said solution comprises a pharmaceutically acceptable organic solvent in an amount of from 50% to 75% by weight of said solution, and said solvent includes: (a) a pharmaceutically acceptable medium and/or long chain fatty acid, or a mixture of pharmaceutically acceptable medium and/or long chain fatty acids, in an amount of from 30% to 75% by weight of said solution; and (c) ethanol or propylene glycol in an amount of from 1% to 15% by weight of said solution. 8. The composition of claim 1, wherein said solution comprises water in an amount of from 0.4% to 1.5% by weight of said solution. 9. The composition according to claim 1, wherein said solution comprises oleic acid in an amount of from 30% to 75% by weight of said solution. 10. The composition according to claim 1, wherein said surfactant is polyoxyl 35 castor oil. 11. The composition according to claim 1, wherein said solution comprises: (a) ritonavir in an amount from 1% to 30% by weight of said solution; (b) a pharmaceutically acceptable medium and/or long chain fatty acid in an amount of from 30% to 75% by weight of said solution; (c) ethanol in an amount of from 1% to 15% by weight of said solution; (d) water in an amount of from 0.4% to 3.5% by weight of said solution; and (e) polyoxyl 35 castor oil in an amount of from 0% to 20% by weight of said solution. 12. The composition of claim 1, wherein said solution comprises: (a) a combination of ritonavir and (2S, 3S, 5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-[2S-(1-tetrahydropyrim- id-2-onyl)-3-methylbutanoyl]-amino-1,6-diphenylhexane, in an amount of from 1% to 45% by weight of said solution; (b) a pharmaceutically acceptable medium and/or long chain fatty acid in an amount of from 30% to 75% by weight of said solution; (c) propylene glycol in an amount of from 1% to 15% by weight of said solution; (d) water in an amount of from 0.4% to 3.5% by weight of said solution; and (e) polyoxyl 35 castor oil in an amount of from 0% to 20% by weight of said solution. 13. The composition according to claim 1, wherein said solution comprises: (a) ritonavir in an amount from 1% to 30% by weight of said solution; (b) oleic acid in an amount of from 30% to 75% by weight of said solution; (c) ethanol in an amount of from 1% to 15% by weight of said solution; (d) water in an amount of from 0.4% to 3.5% by weight of said solution; and (e) polyoxyl 35 castor oil in an amount of from 0% to 20% by weight of said solution. 14. The composition according to claim 13, wherein said solution comprises: (a) ethanol in an amount of from 3% to 12% by weight of said solution; and (b) polyoxyl 35 castor oil in an amount of from 2.5% to 10% by weight of said solution. 15. The composition of claim 1, wherein said solution comprises: (a) ritonavir in an amount of 10% by weight of said solution; (b) oleic acid in an amount of from 70% to 75% by weight of said solution; (c) ethanol in an amount of from 3% to 12% by weight of said solution; (d) water in an amount of from 0.4% to 1.5% by weight of said solution; and (e) polyoxyl 35 castor oil in an amount of 6% by weight of said solution. 16. The composition of claim 1, wherein said solution comprises: (a) a combination of ritonavir and (2S, 3S, 5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-[2S-(1-tetrahydropyrim- id-2-onyl)-3-methylbutanoyl]-amino-1,6-diphenylhexane, in an amount of from 1% to 45% by weight of said solution; (b) oleic acid in an amount of from 30% to 75% by weight of said solution; (c) propylene glycol in an amount of from 1% to 8% by weight of said solution; (d) water in an amount of from 0.4% to 3.5% by weight of said solution; and (e) polyoxyl 35 castor oil in an amount of from 0% to 20% by weight of said solution. 17. The composition of claim 1, wherein said solution comprises: (a) a combination of ritonavir and (2S, 3S, 5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-[2S-(1-tetrahydropyrim- id-2-onyl)-3-methylbutanoyl]-amino-1,6-diphenylhexane, in an amount of 10% by weight of said solution; (b) oleic acid in an amount of from 70% to 75% by weight of said solution; (c) propylene glycol in an amount of from 1% to 15% by weight of said solution; (d) water in an amount of from 0.4% to 1.5% by weight of said solution; and (e) polyoxyl 35 castor oil in an amount of 6% by weight of said solution. 18. The composition according to claim 1, further comprising a hard or soft elastic gelatin capsule which encapsulates said solution. 19. The composition according to claim 3, further comprising a hard or soft elastic gelatin capsule which encapsulates said solution. 20. The composition according to claim 9, further comprising a hard or soft elastic gelatin capsule which encapsulates said solution. 21. The composition according to claim 11, further comprising a hard or soft elastic gelatin capsule which encapsulates said solution. 22. The composition according to claim 12, further comprising a hard or soft elastic gelatin capsule which encapsulates said solution. 23. The composition according to claim 13, further comprising a hard or soft elastic gelatin capsule which encapsulates said solution. 24. The composition according to claim 15, further comprising a hard or soft elastic gelatin capsule which encapsulates said solution. 25. The composition according to claim 16, further comprising a hard or soft elastic gelatin capsule which encapsulates said solution. 26. The composition according to claim 17, further comprising a hard or soft elastic gelatin capsule which encapsulates said solution. |