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Details for Patent: 7,122,206

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Details for Patent: 7,122,206

Title:Aqueous-based pharmaceutical composition
Abstract: An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the position in unsheared form is relatively high, with the composition being in gel-like form; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (D) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity, a method of use of the composition and a method for preparation of the composition, including in preferred form the use of anti-inflammatory steroid, for example, triamcinoline acetonide, and an odorless form of the composition.
Inventor(s): Kim; Soo-Il (Maple Glen, PA)
Assignee: Aventis Pharmaceuticals Holding Inc. (Greenville, DE)
Filing Date:Apr 23, 2002
Application Number:10/128,154
Claims:1. A method for treating allergic rhinitis in an individual by applying solid particles of a medicament selected from the group consisting of dexamethasone and prednisolone to the mucosal surfaces of the nasal cavities of the individual comprising spraying into each of said nasal cavities a dose of an aqueous pharmaceutical composition containing: (A) said medicament and (B) a suspending agent in an amount which is effective in maintaining said particles dispersed uniformly in the composition and in imparting to the composition thixotropic properties such that pharmaceutically effective amounts of the medicament are deposited by aid dose on each of the mucosal surfaces of the anterior regions of the nose, the frontal sinus and the maxillary sinuses and on each of the mucosal surfaces which overlie the turbinates covering the conchas and such that portions of said amounts are retained on each of said mucosal surfaces for at least about an hour.

2. An article of manufacture comprising: (A) n aqueous pharmaceutical composition which comprises: a pharmaceutically effective amount of solid particles of dexamethasone or prednisolone which are effective in treating an abnormal bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity and a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the composition in unsheared form is relatively high, with the composition being a gel having said particles suspended therein; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (iii) in deposited form the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity; (B) vessel which contains said composition; and (C) precompression pump which is associated with the vessel and which is capable of spraying a full dose of the composition into the nostril of an individual.
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