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Generated: October 17, 2017

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Title:Fusion proteins comprising DP-178 and other viral fusion inhibitor peptides useful for treating aids
Abstract: The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
Inventor(s): Bolognesi; Dani Paul (Durham, NC), Matthews; Thomas James (Durham, NC), Wild; Carl T. (Durham, NC), Barney; Shawn O'Lin (Cary, NC), Lambert; Dennis Michael (Cary, NC), Petteway; Stephen Robert (Cary, NC), Langlois; Alphonse J. (Durham, NC)
Assignee: Duke University (Durham, NC)
Filing Date:Oct 09, 2002
Application Number:10/267,748
Claims:1. A fusion protein comprising a macromolecular carrier group fused to a gp41-derived peptide, wherein: (a) the macromolecular carrier group comprises a peptide group; and (b) the gp41-derived peptide consists of the amino acid sequence of SEQ ID NO:1, wherein the fusion protein exhibits anti-HIV activity.

2. A fusion protein comprising a macromolecular carrier group fused to a gp41-derived peptide, wherein: (a) the macromolecular carrier group comprises a peptide group; (b) the gp41-derived peptide consists of the amino acid sequence of SEQ ID NO:210 having from 1 to 22 contiguous amino acids truncated from its amino terminus, wherein the fusion protein exhibits anti-HIV activity.

3. A fusion protein comprising a macromolecular carrier group fused to a gp41-derived peptide, wherein: (a) the macromolecular carrier group comprises a peptide group; (b) the gp41-derived peptide consists of the amino acid sequence of SEQ ID NO:210 having from 1 to 22 contiguous amino acids truncated from its carboxy terminus, wherein the fusion protein exhibits anti-HIV activity.

4. A fusion protein comprising a macromolecular carrier group fused to a gp41-derived peptide, wherein: (a) the macromolecular carrier group comprises a peptide group; (b) the gp41-derived peptide consists of the amino acid sequence of SEQ ID NO:210 having from 1 to 22 contiguous amino acids truncated from its amino terminus and from 1 to 22 contiguous amino acids truncated from its carboxy terminus, wherein the fusion protein exhibits anti-HIV activity.

5. A fusion protein comprising a macromolecular carrier group fused to a gp41-derived peptide, wherein: (a) the macromolecular carrier group comprises a peptide group; (b) the gp41-derived peptide consists of the amino acid sequence of SEQ ID NO: 160 having from 1 to 7 contiguous amino acids truncated from its amino terminus, wherein the fusion protein exhibits anti-HIV activity.

6. A fusion protein comprising a macromolecular carrier group fused to a gp41-derived peptide, wherein: (a) the macromolecular carrier group comprises a peptide group; (b) the gp41-derived peptide consists of the amino acid sequence of SEQ ID NO:160 having from 1 to 13 contiguous amino acids truncated from its carboxy terminus, wherein the fusion protein exhibits anti-HIV activity.

7. A fusion protein comprising a macromolecular carrier group fused to a gp41-derived peptide, wherein: (a) the macromolecular carrier group comprises a peptide group; (b) the gp41-derived peptide consists of the amino acid sequence of SEQ ID NO: 160 having from 1 to 7 contiguous amino acids truncated from its amino terminus and from 1 to 13 contiguous amino acids truncated from its carboxy terminus, wherein the fusion protein exhibits anti-HIV activity.

8. The fusion protein of claim 1, 2, 3, 4, 5, 6 or 7, wherein the peptide group comprises a polypeptide.

9. A recombinant vector comprising a nucleic acid molecule encoding the fusion protein of claim 1, 2, 3, 4, 5, 6 or 7.
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