|Title:||Nucleic acid ligands to integrins|
|Abstract:||Methods are described for the isolation of nucleic acid ligands to integrins using the SELEX process. SELEX is an acronym for Systematic Evolution of Ligands by EXponential enrichment. The nucleic acid ligands of the present invention are useful as therapeutic and diagnostic agents.|
|Inventor(s):||Ruckman; Judy (Boulder, CO), Gold; Larry (Boulder, CO), Stephens; Andrew (Boulder, CO), Janjic; Nebojsa (Boulder, CO)|
|Assignee:||Gilead Sciences, Inc. (Foster City, CA)|
|Filing Date:||Dec 18, 2001|
|Claims:||1. A method for detecting a site of deep vein thrombosis in an individual, the method comprising: (a) providing a nucleic acid ligand to a .alpha..sub.v.beta..sub.3 or .alpha..sub.IIb.beta..sub.3 mtegrm dimer, wherein said ligand binds to a nucleic acid binding site in said integrin .beta..sub.3 and said nucleic acid ligand conjugated to a radioactive label and wherein said nucleic acid ligand is selected from Table 1, 2 or 3; (b) administering said nucleic acid ligand to said individual; (c) detecting the site of said thrombosis by analyzing the localization of said nucleic acid ligand using a radioimaging technique. |
2. A clot-detection composition comprising a nucleic acid ligand to a .alpha..sub.v.beta..sub.3 or .alpha..sub.IIb.beta..sub.3 integrin and a pharmaceutically-acceptable excipient, wherein said ligand binds to a nucleic acid binding site in said integrin .beta..sub.3 and wherein said nucleic acid ligand is selected from Table 1, 2 or 3.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.