.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 7,067,483

« Back to Dashboard

Details for Patent: 7,067,483

Title:Pharmaceutical compositions containing a gycopeptide antibiotic and a cyclodextrin
Abstract: Disclosed are pharmaceutical composition containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering said pharmaceutical composition.
Inventor(s): Judice; J. Kevin (El Granada, CA), Shaw; Jeng Pyng (Saratoga, CA), Mu; YongQi (Los Altos, CA), Conner; Michael W. (Half Moon Bay, CA), Pace; John L. (San Anselmo, CA)
Assignee: Theravance, Inc. (South San Francisco, CA)
Filing Date:Aug 31, 2004
Application Number:10/931,122
Claims:1. A method for reducing tissue accumulation of a lipidated glycopeptide antibiotic in a mammal, the method comprising administering a therapeutically effective amount of the lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof to the mammal in a pharmaceutical composition comprising a cyclodextrin, wherein the lipidated glycopeptide antibiotic accumulates in the mammal in the absence of the cyclodextrin.

2. The method of claim 1, wherein the pharmaceutical composition further comprises water.

3. A method for reducing tissue accumulation of a lipidated glycopeptide antibiotic in a mammal, the method comprising administering a therapeutically effective amount of the lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof to the mammal in a pharmaceutical composition comprising an aqueous cyclodextrin carrier, wherein the lipidated glycopeptide antibiotic accumulates in the mammal in the absence of the cyclodextrin.

4. A method for reducing tissue accumulation of a lipidated glycopeptide antibiotic in a mammal, the method comprising administering a therapeutically effective amount of the lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof to the mammal in a pharmaceutical composition comprising 1 to 40 weight percent of a cyclodextrin; and 60 to 99 weight percent of water, based on 100 weight percent of the composition, wherein the lipidated glycopeptide antibiotic accumulates in the mammal in the absence of the cyclodextrin.

5. The method of claim 4, wherein the cyclodextrin comprises about 5 to 35 weight percent of the composition.

6. The method of claim 4, wherein the cyclodextrin comprises about 10 to 30 weight percent of the composition.

7. The method of any one of claims 1 to 6, wherein the cyclodextrin is hydroxypropyl-.alpha.-cyclodextrin.

8. The method of any one of claims 1 to 6, wherein the cyclodextrin is sulfobutyl ether .beta.-cyclodextrin.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc