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Details for Patent: 7,026,288

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Details for Patent: 7,026,288

Title:Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
Abstract: Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
Inventor(s): Judice; J. Kevin (El Granada, CA), Shaw; Jeng Pyng (Saratoga, CA), Mu; YongQi (Los Altos, CA), Conner; Michael W. (Half Moon Bay, CA), Pace; John L. (San Anselmo, CA)
Assignee: Theravance, Inc. (South San Francisco, CA)
Filing Date:Aug 31, 2004
Application Number:10/930,585
Claims:1. A method for reducing nephrotoxicity produced by a lipidated glycopeptide antibiotic in a mammal, the method comprising administering a therapeutically effective amount of the lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof to the mammal in a pharmaceutical composition comprising a cyclodextrin, wherein the lipidated glycopeptide antibiotic produces nephrotoxicity in the mammal in the absence of the cyclodextrin.

2. The method of claim 1, wherein the pharmaceutical composition further comprises water.

3. A method for reducing nephrotoxicity produced by a lipidated glycopeptide antibiotic in a mammal, the method comprising administering a therapeutically effective amount of the lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof to the mammal in a pharmaceutical composition comprising: (a) an aqueous cyclodextrin carrier, wherein the lipidated glycopeptide antibiotic produces nephrotoxicity in the mammal in the absence of the cyclodextrin.

4. A method for reducing nephrotoxicity produced by a lipidated glycopeptide antibiotic in a mammal, the method comprising administering a therapeutically effective amount of the lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof to the mammal in a pharmaceutical composition comprising: (a) 1 to 40 weight percent of a cyclodextrin; and 60 to 99 weight percent of water, based on 100 weight percent of the composition, wherein the lipidated glycopeptide antibiotic produces nephrotoxicity in the mammal in the absence of the cyclodextrin.

5. The method of claim 4, wherein the cyclodextrin comprises about 5 to 35 weight percent of the composition.

6. The method of claim 4, wherein the cyclodextrin comprises about 10 to 30 weight percent of the composition.

7. The method of any one of claims 1 to 6, wherein the cyclodextrin is hydroxypropyl-.beta.-cyclodextrin.

8. The method of any one of claims 1 to 6, wherein the cyclodextrin is sulfobutyl ether .beta.-cyclodextrin.
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