Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Piperidine derivatives and process for their production|
|Abstract:||The present invention relates to substantially pure piperidine derivative compounds of the formulae: ##STR00001## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2; R.sub.3 is --COOH or --COOR.sub.4; R.sub.4 has 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings, each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents. A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.|
|Inventor(s):||D'Ambra; Thomas E. (Wynantskill, NY)|
|Assignee:||AMR Technology , Inc. (Manchester, VT)|
|Filing Date:||Aug 13, 2004|
|Claims:||1. A compound of the formula: ##STR00042## wherein A is one or more substituents, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy or alkoxy; R.sub.5 is --N(R.sub.6).sub.2; and R.sub.6 is an alkyl with 1 to 6 carbons. |
2. A process of preparing a mixture of regioisomers of the formula: ##STR00043## wherein A is one or more substituents, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy or alkoxy; R.sub.5 is --N(R.sub.6).sub.2; and R.sub.6 is an alkyl with 1 to 6 carbons; said process comprising: acylating a starting compound of the formula: ##STR00044## with a compound of the formula: ##STR00045## wherein X is a halogen.
3. A process according to claim 2, wherein said acylating is carried out by a Friedel-Crafts reaction using AlCl.sub.3 catalyst.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.