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|Title:||Methods for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women|
|Abstract:||This invention relates to a method for inhibition of skin atrophy, or epithelial or mucosal atrophy in women, or to a method for treatment or prevention of symptoms related to said atrophy, said method comprising administering to the woman an effective amount of the compound of formula (I) ##STR00001## or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof.|
|Inventor(s):||Blom; Taru (Nousiainen, FI), Gronroos; Paula (Turku, FI), Halonen; Kaija (Rusko, FI), Harkonen; Pirkko (Turku, FI)|
|Assignee:||Hormos Medical Corporation (Turku, FI)|
|Filing Date:||Jun 06, 2002|
|Claims:||1. A method for treatment or prevention of urinary symptoms related to urogenital atrophy in women, said method comprising administering to a woman an effective amount of the compound of formula (I) ##STR00004## or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof wherein the urinary symptoms are micturation disorders, dysuria, hematuria, urinary frequency, sensation of urgency, urinary tract infections, urinary tract inflammation, nocturia or involuntary urinary leakage. |
2. The method according to claim 1 wherein compound (I) is ospemifene.
3. The method according to claim 1 wherein compound (I), its isomer, salt or ester is administered orally, topically, transdermally, intravaginally or subcutaneously.
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