|Title:||Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof|
|Abstract:||The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an effective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.|
|Inventor(s):||Youdim; Moussa B. H. (Tivon, IL), Finberg; John P. M. (Tivon, IL), Levy; Ruth (Tel-Aviv, IL), Sterling; Jeffrey (Jerusalem, IL), Lerner; David (Jerusalem, IL), Yellin; Haim (Ramat-Gan, IL), Veinberg; Alex (Rehovot, IL)|
|Assignee:||Teva Pharmaceutical Industries, Ltd. (Petach-Tikva, IL) Technion Research and Development Foundation Ltd. (Haifa, IL)|
|Filing Date:||Nov 27, 2002|
|Claims:||1. A pharmaceutically acceptable salt of R(+)-N-propargyl-1-aminoindan, wherein the salt is the tartrate salt. |
2. A pharmaceutical composition consisting essentially of the pharmaceutically acceptable salt of claim 1 and a pharmaceutically acceptable carrier.
3. A pharmaceutical composition comprising the pharmaceutically acceptable salt of claim 1 and a pharmaceutically acceptable carrier.
4. A pharmaceutical composition consisting of the pharmaceutically acceptable salt of claim 1 and a pharmaceutically acceptable carrier.
5. A pharmaceutical composition consisting of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt and a carrier.
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