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Details for Patent: 6,956,043

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Details for Patent: 6,956,043

Title: Pharmaceutical compositions comprising 33-epi-chloro-33-desoxy-ascomycin solid dispersions
Abstract:A pharmaceutical composition in the form of a solid dispersion comprising a macrolide, e.g. a rapamycin or an ascomycin, and a carrier medium.
Inventor(s): Guitard; Patrice (Hegenheim, FR), Haeberlin; Barbara (Riehen, CH), Link; Rainer (Staufen, DE), Richter; Friedrich (Grenzach-Wyhlen, DE)
Assignee: Novartis AG (Basel, CH)
Filing Date:Jun 04, 2003
Application Number:10/454,017
Claims:1. A pharmaceutical composition for oral administration comprising a solid dispersion of 33-epi-chloro-33-desoxy-ascomycin with a carrier medium, which carrier medium comprises a water-soluble polymer or a cyclodextrin, and further comprises a surfactant.

2. A pharmaceutical composition as claimed in claim 1 wherein the carrier medium comprises a water-soluble polymer.

3. A pharmaceutical composition as claimed in claim 2 wherein the water-soluble polymer comprises hydroxypropylmethylcellulose or polyvinylpyrrolidone.

4. A pharmaceutical composition as claimed in claim 3 wherein the water-soluble polymer comprises hydroxypropylmethylcellulose.

5. A pharmaceutical composition as claimed in claim 1 wherein the surfactant comprises a polyoxyethylene-polyoxypropylene block co-polymer.

6. A pharmaceutical composition as claimed in claim 1 wherein the composition further comprises a lactose.

7. A pharmaceutical composition as claimed in claim 1 wherein the composition further comprises a disintegrant.

8. A pharmaceutical composition as claimed in claim 1 wherein the composition comprises up to 30% by weight of 33-epi-chloro-33-desoxy-ascomycin based on the total weight of the composition.

9. A pharmaceutical composition as claimed in claim 4 wherein the water-soluble polymer comprises hydroxypropylmethylcellulose in an amount of up to 95% by weight, based on the total weight of the composition.
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