Details for Patent: 6,906,031
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Title: | Polyacid glycopeptide derivatives |
Abstract: | Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO.sub.2 H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents. |
Inventor(s): | Linsell; Martin S. (San Mateo, CA), Judice; J. Kevin (El Granada, CA) |
Assignee: | Theravance, Inc. (South San Francisco, CA) |
Filing Date: | Jun 25, 2004 |
Application Number: | 10/877,751 |
Claims: | 1. A compound of formula II: ##STR11## wherein R.sup.a is --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 --; R.sup.b and Z form an n-octyl, n-nonyl, n-decyl, n-undecyl or n-dodecyl group; or a pharmaceutically acceptable salt or stereoisomer thereof. 2. The compound of claim 1, wherein R.sup.a is --CH.sub.2 CH.sub.2 --. 3. The compound of claim 2, wherein R.sup.b and Z form an n-decyl group. 4. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of any one of claims 1, 2 or 3. 5. The pharmaceutical composition of claim 4, wherein the composition further comprises a cyclodextrin. 6. The pharmaceutical composition of claim 5, wherein the cyclodextrin is hydroxypropyl-.beta.-cyclodextrin or sulfobutyl ether .beta.-cyclodextrin. 7. A method of treating a bacterial disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a compound of any one of claims 1, 2 or 3. |