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Details for Patent: 6,906,031

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Details for Patent: 6,906,031

Title: Polyacid glycopeptide derivatives
Abstract:Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO.sub.2 H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
Inventor(s): Linsell; Martin S. (San Mateo, CA), Judice; J. Kevin (El Granada, CA)
Assignee: Theravance, Inc. (South San Francisco, CA)
Filing Date:Jun 25, 2004
Application Number:10/877,751
Claims:1. A compound of formula II: ##STR11## wherein R.sup.a is --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 --; R.sup.b and Z form an n-octyl, n-nonyl, n-decyl, n-undecyl or n-dodecyl group; or a pharmaceutically acceptable salt or stereoisomer thereof.

2. The compound of claim 1, wherein R.sup.a is --CH.sub.2 CH.sub.2 --.

3. The compound of claim 2, wherein R.sup.b and Z form an n-decyl group.

4. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of any one of claims 1, 2 or 3.

5. The pharmaceutical composition of claim 4, wherein the composition further comprises a cyclodextrin.

6. The pharmaceutical composition of claim 5, wherein the cyclodextrin is hydroxypropyl-.beta.-cyclodextrin or sulfobutyl ether .beta.-cyclodextrin.

7. A method of treating a bacterial disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a compound of any one of claims 1, 2 or 3.
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