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Generated: July 23, 2017

DrugPatentWatch Database Preview

Details for Patent: 6,903,224

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Details for Patent: 6,903,224

Title: Substituted 1,3-oxathiolanes
Abstract:Substituted 1,3-oxathiolanes, such as cis- and trans-2-ethoxycarbonyl-5-hydroxy-1,3-oxathiolane and cis- and trans-2-ethoxycarbonyl-5-acetoxy-1,3-oxathiolane, are suitable as intermediates for the production of substituted 1,3-oxathiolanes nucleoside analogs having antiviral properties.
Inventor(s): Belleau; Bernard (late of Montreal, CA), Belleau; Pierette (Montreal, CA), Dixit; Dilip M. (Roxoboro, CA), Nguyen-Ba; Nghe (La Prairie, CA)
Assignee: BioChem Pharma Inc. (Laval, CA)
Filing Date:Feb 12, 2002
Application Number:10/073,116
Claims:1. A compound selected from the group consisting of: cis- and trans-2-ethoxycarbonyl-5-hydroxy-1,3-oxathiolane; cis- and trans-2-ethoxycarbonyl-5-acetoxy- 1,3-oxathiolane; cis- and trans-2-ethoxycarbonyl-5-(methoxycarbonyloxy)-1,3-oxathiolane; cis- and trans-2-t-butyldiphenylsilyloxy-methyl-5-(methoxycarbonyloxy)-1,3-oxathiol ane; cis- and trans-2-benzoyloxymethyl-5-(2-methoxyethoxy)-1,3-oxathiolane; cis- and trans-2-hydroxymethyl-5-hydroxy-1,3-oxathiolane; and cis- and trans-2-acetoxymethyl-1,3-oxathiolane.

2. A compound according to claim 1, wherein said compound is cis-2-ethoxycarbonyl-5-hydroxy-1,3-oxathiolane.

3. A compound according to claim 1, wherein said compound is trans-2-ethoxycarbonyl-5-hydroxy-1,3-oxathiolane.

4. A compound according to claim 1, wherein said compound is cis-2-ethoxycarbonyl-5-acetoxy-1,3-oxathiolane.

5. A compound according to claim 1, wherein said compound is trans-2-ethoxycarbonyl-5-acetoxy-1,3-oxathiolane.

6. A compound according to claim 1, wherein said compound is cis-2-ethoxycarbonyl-5-(methoxycarbonyloxy)-1,3-oxathiolane.

7. A compound according to claim 1, wherein said compound is trans-2-ethoxycarbonyl-5-(methoxycarbonyloxy)-1,3-oxathiolane.

8. A compound according to claim 1, wherein said compound is cis-2-t-butyldiphenylsilyloxy-methyl-5-(methoxycarbonyloxy)-1,3-oxathiolan e.

9. A compound according to claim 1, wherein said compound is trans-2-t-butyldiphenylsilyloxy-methyl-5-(methoxycarbonyloxy)-1,3-oxathiol ane.

10. A compound according to claim 1, wherein said compound is cis-2-benzoyloxymethyl-5-(2-methoxyethoxy)-1,3-oxathiolane.

11. A compound according to claim 1, wherein said compound is trans-2-benzoyloxymethyl-5-(2-methoxyethoxy)-1,3-oxathiolane.

12. A compound according to claim 1, wherein said compound is cis-2-hydroxymethyl-5-hydroxy-1,3-oxathiolane.

13. A compound according to claim 1, wherein said compound is trains-2-hydroxymethyl-5-hydroxy-1,3-oxathiolane.

14. A compound according to claim 1, wherein said compound is cis-2-acetoxymethyl-1,3-oxathiolane.

15. A compound according to claim 1, wherein said compound is trans-2-acetoxymethyl-1,3-oxathiolane.
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