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|Title:||Preparation and use of oligopeptide lyophilisate for gonad protection|
|Abstract:||A lyophilizate, method of preparation, and use of the lyophilizate for gonad protection is described. The lyophilizate comprises cetrorelix dissolved in 30% (v/v) acetic acid, transferred to water, and freeze-dried.|
|Inventor(s):||Engel; Jurgen (Alzenau, DE), Wichert; Burkhard (Bielefeld, DE), Sauerbier; Dieter (Werter, DE), Reissmann; Thomas (Frankfurt am Main, DE)|
|Assignee:||Zentaris GmbH (Frankfurt, DE)|
|Filing Date:||May 24, 2002|
|Claims:||1. A method for providing male gonad protection against radiation therapy or treatment with cytostatics, the method comprising administering to a male an effective amount of a pharmaceutical composition comprising a diluent and a lyophilizate of cetrorelix solution in which the lyophilizate was prepared from 100-10,000 parts by weight of acetic acid per part of dissolved cetrorelix; wherein said pharmaceutical composition is administered prior to radiation therapy or treatment with cytostatics. |
2. The method according to claim 1, wherein the lyophilizate further comprises a bulking agent.
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