Anticipate generic drug launch
Proactively manage your pharmacy inventory
Deep knowledge on
small-molecule drugs and
the 110,000 global patents
Find generic entry opportunities
Manage your formulary budget
Drug patents …
… from Kazakhstan to Kalamazoo
Flat-rate pricing for predictable budgeting
Short-term plans for project- or client-based billing
Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Process for the preparation of 4-haloalkylnicotinonitriles|
|Abstract:||4-Haloalkylnicotinonitriles having the formula (I) ##STR1## which are suitable as intermediates in the preparation of pesticides, are obtained by: (a) reacting a 3-amino-1-haloalkyl-2-propen-1-one in a condensation reaction with a compound of the formula (III) to (VII), to give a compound of the formula (VIII), (IX) and/or (X), wherein R.sup.F is (C.sub.1 -C.sub.4)-haloalkyl, R.sup.1 is alkyl, Hal is Cl or Br and each Z, independently, is O, S, NR.sup.1 or OCO; and (b) subjecting the reaction product to a ring closure reaction.|
|Inventor(s):||Pazenok; Sergiy (Kelkheim, DE), Bastiaans; Henricus Maria Martinus (Usingen, DE)|
|Assignee:||Aventis CropScience GmbH (Frankfurt, DE)|
|Filing Date:||Dec 30, 2002|
|Claims:||1. A compound having the formula (VIII), (IX) or (X): |
wherein: R.sup.F is (C.sub.1 -C.sub.4)-haloalkyl; R.sup.1 is an alkyl group; Z is O, S or OCO and Hal is Cl or Br.
2. A compound as claimed in claim 1, wherein R.sup.F is CH.sub.2 F, CFCl.sub.2, CF.sub.2 Cl, CF.sub.3 or C.sub.2 F.sub.5.
3. A compound as claimed in claim 2, wherein R.sup.F is CF.sub.3.
4. A compound as claimed in claim 1, wherein Z is O or OCO.
5. A compound as claimed in claim 4, wherein R.sup.1 is (C.sub.1 -C.sub.4)-alkyl.
6. A compound as claimed in claim 5, wherein R.sup.1 is methyl or ethyl.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.