.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 6,858,593

« Back to Dashboard

Details for Patent: 6,858,593

Title: Anti-inflammatory androstane derivative compositions
Abstract:There is provided a crystalline chemical composition comprising a compound of formula (I) ##STR1## in which the crystal lattice is stabilized by the presence of a guest molecule, characterized in the crystalline composition is of space group P2.sub.1 2.sub.1 2.sub.1 having unit cell dimensions of about 7.6.+-.0.6 .ANG., 12.7.+-.0.7 .ANG., and 33.+-.3 .ANG. when determined at 120 K.
Inventor(s): Biggadike; Keith (Stevenage, GB), Chetina; Olga (Durham, GB), Coote; Steven John (Stevenage, GB), Craig; Andrew (Tonbridge, GB), Jacewicz; Victor (Tonbridge, GB), Millan; Michael J. (Tonbridge, GB), Seager; John F. (Stevenage, GB), Theophilus; Andrew L. (Stevenage, GB)
Assignee: Smithkline Beecham Corporation (Philadelphia, PA)
Filing Date:Jul 22, 2002
Application Number:10/200,364
Claims:1. A crystalline chemical composition comprising a compound of formula (I) ##STR8##

in which the crystal lattice is stabilised by the presence of a guest molecule, characterised in the crystalline composition is of space group P2.sub.1 2.sub.1 2.sub.1 having unit cell dimensions of about 7.6.+-.0.6 .ANG., 12.7.+-.0.7 .ANG., and 33.+-.3 .ANG. when determined at 120 K.

2. A composition according to claim 1 wherein the guest molecule preferably has a relative molecular weight in the range 16 to 150.

3. A composition according to claim 1 wherein the guest molecule conains a moiety capable of acting as a hydrogen bond acceptor.

4. A composition according to claim 1 wherein the guest molecule is diethylamine.

5. A composition according to claim 1 wherein the guest molecule is triethylamine.

6. A composition according to claim 1 wherein the guest molecule is dipropylamine.

7. A composition according to claim 1 wherein the ratio of compound of formula (I) to guest molecule is 1:2.0-0.3.

8. A pharmaceutical composition comprising a composition according to claim 1 together with a physiologically acceptable diluent or carrier.

9. A method for the treatment of a human or animal subject with an inflammatory and/or allergic condition, which method comprises administering to said human or animal subject an effective amount of the composition according to claim 1.

10. A pharmaceutical composition comprising a composition according to claim 1 in combination with another therapeutically active agent.

11. A composition according to claim 10 wherein the other therapeutically active ingredient is a long acting .beta..sub.2 -adrenoreceptor agonist.

12. A process for preparing a composition according to claim 1 which comprises (a) crystallising the composition from a solution containing a compound of formula (I) and the guest molecule; or (b) contacting the compound of formula (I) or another composition according claim 1 in solid form with a liquid containing the guest molecule and obtaining the composition therefrom; or (c) contacting a compound of formula (I) or another composition according to claim 1 in solid form with a vapour containing the guest molecule.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc