Details for Patent: 6,828,313
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Title: | Use of oxandrolone in the treatment of burns and other wounds |
Abstract: | The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The invention also provides a method of treating a wound in a patient suffering from a wound which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The subject invention further provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone in conjunction with a protein supplement to the patient. |
Inventor(s): | Fishbein; Don (Westfield, NJ) |
Assignee: | Savient Pharmaceuticals, Inc. (East Brunswick, NJ) |
Filing Date: | Oct 22, 2001 |
Application Number: | 10/011,377 |
Claims: | 1. A method of increasing the rate of healing of a skin wound in a patient suffering from a skin wound which comprises administering a therapeutically effective amount of oxandrolone to the patient. 2. A method according to claim 1 wherein the skin wound is an ulcer. 3. A method according to claim 2 wherein the ulcer is a decubitus ulcer or a diabetic ulcer. 4. A method according to claim 1 wherein the skin wound comprises a skin graft. 5. A method according to claim 1 wherein the skin wound is a burn. 6. A method according to claim 1 wherein the amount of oxandrolone is about 1-100 mg per day. 7. A method according to claim 6 wherein the amount of oxandrolone is about 80 mg per day. 8. A method according to claim 6 wherein the amount of oxandrolone is about 20 mg per day. 9. A method according to claim 6 wherein the amount of oxandrolone is about 10 mg per day. 10. A method according to claim 6 wherein the amount of oxandrolone is about 2.5 mg per day. 11. A method according to claim 1 wherein the oxandrolone is administered orally. 12. A method according to claim 1 wherein the oxandrolone is administered topically. 13. A method according to claim 1 wherein the oxandrolone is administered by injection. 14. A method according to claim 1 wherein the oxandrolone is in a solid dosage form. 15. A method according to claim 1 wherein the oxandrolone is in a liquid dosage form. 16. A method according to claim 1 wherein the oxandrolone is in a sustained-release formulation. 17. A method according to claim 1 wherein the oxandrolone is 17.alpha.-methyl-17.beta.-hydroxy-2-oxa-5.alpha.-androstan-3-one. 18. A method of increasing the rate of weight gain during the recovery phase after burn-induced weight loss in a patient having a burn wound which comprises administering a therapeutically effective amount of oxandrolone to the patient. 19. A method according to claim 18 wherein the amount of oxandrolone is about 1-100 mg per day. 20. A method according to claim 19 wherein the amount of oxandrolone is about 80 mg per day. 21. A method according to claim 19 wherein the amount of oxandrolone is about 20 mg per day. 22. A method according to claim 19 wherein the amount of oxandrolone is about 10 mg per day. 23. A method according to claim 19 wherein the amount of oxandrolone is about 2.5 mg per day. 24. A method according to claim 18 wherein the oxandrolone is administered orally. 25. A method according to claim 18 wherein the oxandrolone is administered topically. 26. A method according to claim 18 wherein the oxandrolone is administered by injection. 27. A method according to claim 18 wherein the oxandrolone is in a solid dosage form. 28. A method according to claim 18 wherein the oxandrolone is in a liquid dosage form. 29. A method according to claim 18 wherein the oxandrolone is in a sustained-release formulation. 30. A method according to claim 18 wherein the oxandrolone is 17.alpha.-methyl-17.beta.-hydroxy-2-oxa-5.alpha.-androstan-3-one. 31. A method according to claim 18 further comprising administering a protein supplement. 32. A method according to claim 18 wherein the weight comprises lean body mass. 33. A method according to claim 18 wherein the weight gained is maintained. |