|Title:||2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses|
|Abstract:||The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, ##STR1## wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.|
|Inventor(s):||Differding; Edmond (Louvain-la-Neuve, BE), Kenda; Benoit (Emines, BE), Lallemand; Benedicte (Waimes, BE), Matagne; Alain (Gerpinnes, BE), Michel; Philippe (Beersel, BE), Pasau; Patrick (Chastre, BE), Talaga; Patrice (Watermael-Boitsfort, BE)|
|Assignee:||UCB, S.A. (Brussels, BE)|
|Filing Date:||Oct 28, 2003|
|Claims:||1. (2S)-2-[(4S)-4-(2,2-difluorovinyl)-2-oxopyrrolidinyl]butanamide or a pharmaceutically acceptable salt thereof. |
2. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 in combination with a pharmaceutically acceptable diluent or carrier.
3. A method for treating epilepsy, epileptogenesis, seizure disorders, convulsions bipolar disorders, mania, depression, anxiety, migraine, neuralgia, chronic pain, neuropathic pain, cerebral ischemia, essential tremor, neonatal cerebral haemorrhage, amyotrophic lateral sclerosis, spasticity, Parkinson's disease, in a mammal in need of such treatment, comprising administering a therapeutic does of at least one compound according to claim 1.
4. The method according to claim 3, wherein the condition to be treated is epilepsy, neuropathic pain, bipolar disorder or migraine.