Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Oral 2-methyl-thieno-benzodiazepine formulation|
|Abstract:||The invention provides a pharmaceutically elegant solid oral formulation of olanzapine and a process for making such formulation.|
|Inventor(s):||Cochran; George Randall (Plainfield, IN), Morris; Tommy Clifford (Indianapolis, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
|Filing Date:||Jan 19, 2001|
|Claims:||1. A method for preparing a stable pharmaceutically elegant solid oral formulation of olanzapine having a polymer coating selected from the group consisting of hydroxypropyl methyl cellulose, hydroxyethyl cellulose, methylhydroxyethylcellulose, sodium carboxymethylcellulose, hydroxypropylcellulose, polyvinyl pyrrolidone, dimethylaminoethyl methacrylatemethylacrylate acid ester copolymer, ethylacrylate-methylacrylate copolymer, methylcellulose, and ethylcellulose, wherein the polymer coating is free of polyethylene glycol, comprised of using a high shear aqueous wet granulation with fluid bed drying. |
2. A method according to claim 1 wherein the polymer coating is selected from the group consisting of hydroxypropyl methyl cellulose, hydroxypropylcellulose, methylcellulose, and ethylcellulose.
3. A method according to claim 1 wherein the polymer coating is hydroxypropyl methyl cellulose.
4. A method according to claim 1 wherein olanzapine is the substantially pure anhydrous Form I crystalline form.
5. A method according to claim 3 wherein olanzapine is the substantially pure anhydrous Form I crystalline form.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.