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Generated: December 12, 2017

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Title: Oral 2-methyl-thieno-benzodiazepine formulation
Abstract:The invention provides a pharmaceutically elegant solid oral formulation of olanzapine and a process for making such formulation.
Inventor(s): Cochran; George Randall (Plainfield, IN), Morris; Tommy Clifford (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Filing Date:Jan 19, 2001
Application Number:09/766,218
Claims:1. A method for preparing a stable pharmaceutically elegant solid oral formulation of olanzapine having a polymer coating selected from the group consisting of hydroxypropyl methyl cellulose, hydroxyethyl cellulose, methylhydroxyethylcellulose, sodium carboxymethylcellulose, hydroxypropylcellulose, polyvinyl pyrrolidone, dimethylaminoethyl methacrylatemethylacrylate acid ester copolymer, ethylacrylate-methylacrylate copolymer, methylcellulose, and ethylcellulose, wherein the polymer coating is free of polyethylene glycol, comprised of using a high shear aqueous wet granulation with fluid bed drying.

2. A method according to claim 1 wherein the polymer coating is selected from the group consisting of hydroxypropyl methyl cellulose, hydroxypropylcellulose, methylcellulose, and ethylcellulose.

3. A method according to claim 1 wherein the polymer coating is hydroxypropyl methyl cellulose.

4. A method according to claim 1 wherein olanzapine is the substantially pure anhydrous Form I crystalline form.

5. A method according to claim 3 wherein olanzapine is the substantially pure anhydrous Form I crystalline form.
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