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Details for Patent: 6,747,155

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Details for Patent: 6,747,155

Title: Process
Abstract:The present invention relates to a novel process for the preparation of the magnesium salt of the (-)-enantiomer of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-ben zimidazole trihydrate, i.e. S-omeprazole magnesium salt trihydrate. The present invention also relates to the S-omeprazole magnesium salt trihydrate prepared in accordance with the new process and pharmaceutical compositions containing it. Furthermore, the present invention also relates to new intermediates used in the process.
Inventor(s): Kronstrom; Anders (Stockholm, SE), Leander; Eva (Skiptvet, NO), Mattson; Anders (Taby, SE), Jansson; Karin (Holo, SE), Bohlin; Martin (Stockholm, SE)
Assignee: AstraZeneca AB (Sodertalje, SE)
Filing Date:Apr 01, 2002
Application Number:10/113,245
Claims:1. A process for the preparation of the magnesium salt of S-omeprazole trihydrate which comprises the following steps: (a) dissolving a magnesium source in water; (b) mixing a potassium salt of S-omeprazole with water; (c) adding the solution of the potassium salt of S-omeprazole of step (b) to the solution of step (a) to convert the potassium salt of S-omeprazole into the corresponding magnesium salt of S-omeprazole and precipitate the magnesium salt of S-omeprazole; (d) isolating the obtained magnesium salt of S-omeprazole; (e) treating the obtained magnesium salt of S-omeprazole with water; and (f) isolating and drying the obtained magnesium salt of S-omeprazole trihydrate.

2. The process according to claim 1, further comprising the step of adding seeding crystals of S-omeprazole magnesium salt trihydrate to the solution of step (a).

3. The process according to claim 1, further comprising the step of washing the solution of step (b) with an organic solvent.

4. The process according to claim 2, further comprising the step of washing the solution of step (b) with an organic solvent.

5. The process according to claim 3 or 4, wherein the organic solvent is toluene.

6. The process according to any one of claims 1-4, wherein the magnesium source is magnesium sulfate.

7. The process according to any one of claims 1-4, wherein the magnesium salt of S-omeprazole trihydrate is characterized by the following major peaks in its X-ray diffractogram:
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