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Details for Patent: 6,716,452

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Details for Patent: 6,716,452

Title: Active agent delivery systems and methods for protecting and administering active agents
Abstract:A composition comprising a polypeptide and an active agent covalently attached to the polypeptide. Also provided is a method for delivery of an active agent to a patient comprising administering to the patient a composition comprising a polypeptide and an active agent covalently attached to the polypeptide. Also provided is a method for protecting an active agent from degradation comprising covalently attaching the active agent to a polypeptide. Also provided is a method for controlling release of an active agent from a composition comprising covalently attaching the active agent to the polypeptide.
Inventor(s): Piccariello; Thomas (Blacksburg, VA), Olon; Lawrence P. (Bristol, TN), Kirk; Randall J. (Radford, VA)
Assignee: New River Pharmaceuticals Inc. (Redford, VA)
Filing Date:Aug 22, 2000
Application Number:09/642,820
Claims:1. A composition comprising: a polypeptide wherein said polypeptide is a heteropolymer of two or more synthetic amino acids; an active agent covalently attached to the side chain of said polypeptide; and wherein said composition is in a form suitable for oral administration and release of said active agent into the bloodstream following oral administration.

2. A composition comprising: a polypeptide; an active agent other than an amino acid wherein said active agent is an amine and wherein said active agent is covalently attached through said amine to the C-terminus of said polypeptide; and wherein said composition is in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration.

3. A composition comprising: a polypeptide; an active agent wherein said active agent is an alcohol and wherein said active agent is covalently attached through said alcohol to the C-terminus of said polypeptide; and wherein said composition is in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration.

4. A composition comprising: a polypeptide; an active agent wherein said active agent is an alcohol and wherein said active agent is covalently attached through said alcohol to the N-terminus of said polypeptide; and wherein said composition is in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration.

5. A method for delivering an active agent to a patient comprising administering to said patient a composition comprising: a polypeptide wherein said polypeptide is covalently attached to an adjuvant wherein said adjuvant is not an amino acid; an active agent other than an amino acid covalently attached to said polypeptide; wherein said composition is in a form suitable for oral administration and release of said active agent into the bloodstream following oral administration; and wherein release of said adjuvant from said composition is controlled by said polypeptide.

6. A composition comprising: a polypeptide wherein said polypeptide consists of one or more of the twenty naturally occurring amino acids, an active agent other than an amino acid wherein said active agent is an amine and wherein said active agent is covalently attached through said amine to the C-terminus of said polypeptide; and wherein said composition is in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration.

7. A composition comprising: a polypeptide wherein said polypeptide consists of one or more of the twenty naturally occurring amino acids, an active agent wherein said active agent is an alcohol which is covalently attached through said alcohol to the C-terminus of said polypeptide; and wherein said composition is in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration.

8. A composition comprising: a polypeptide wherein said polypeptide consists of one or more of the twenty naturally occurring amino acids, an active agent wherein said active agent is an alcohol which is covalently attached through said alcohol to the N-terminus of said polypeptide; and wherein said composition is in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration.

9. A composition comprising: a polypeptide; an active agent other than an amino acid wherein said active agent is an alcohol covalently attached to said polypeptide through said alcohol in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration wherein said composition is in the form of an ingestible tablet, a capsule, or an oral suspension.

10. The composition of claim 9 wherein said polypeptide consists of one or more of the twenty naturally occurring amino acids.

11. The composition of claim 9, wherein said polypeptide consists of one or more amino acids selected from glutamic acid, aspartic acid, arginine, asparagine, cysteine, lysine, threonine, or serine.

12. The composition of claim 11, wherein the polypeptide consists of glutamic acid.

13. The composition of claim 11, wherein the polypeptide consists of serine.

14. The composition of claim 11, wherein the polypeptide consists of lysine.

15. The composition of claims 9, 10, 11, 12, 13 or 14 wherein said active agent is attached through the C-terminus.

16. The composition of claims 9, 10, 11, 12, 13 or 14 wherein said active agent is attached through the N-terminus.

17. The composition of claims 9, 10, 11, 12, 13 or 14 wherein said active agent is attached through the side chain of an amino acid.

18. A composition comprising: a polypeptide; an active agent other than an amino acid wherein said active agent is an amine covalently attached to said polypeptide through said amine in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration wherein said composition is in the form of an ingestible tablet, a capsule or an oral suspension.

19. The composition of claim 18, wherein said polypeptide consists of one or more of the twenty naturally occurring amino acids.

20. The composition of claim 18, wherein said polypeptide consists of one or more amino acids selected from glutamic acid, aspartic acid, arginine, asparagine, cysteine, lysine, threonine, and serine.

21. The composition of claim 20, wherein the polypeptide consists of glutamic acid.

22. The composition of claim 20, wherein the polypeptide consists of serine.

23. The composition of claim 20, wherein the polypeptide consists of lysine.

24. The composition of claims 18, 19, 20, 21, 22, or 23 wherein said active agent is attached through the C-terminus.

25. The composition of claims 18, 19, 20, 21 or 22 wherein said active agent is attached through the side chain of an amino acid.

26. A composition comprising: a polypeptide; an active agent other than an amino acid wherein said active agent is a carboxylic acid covalently attached to said polypeptide through said carboxylic acid in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration wherein said composition is in the form of an ingestible tablet, a capsule, or an oral suspension.

27. The composition of claim 26, wherein said polypeptide consists of one or more of the twenty naturally occurring amino acids.

28. The composition of claim 26, wherein said polypeptide consists of one or more amino acids selected from glutamic acid, aspartic acid, arginine, asparagine, cysteine, lysine, threonine, and serine.

29. The composition of claim 28, wherein the polypeptide consists of glutamic acid.

30. The composition of claim 28, wherein the polypeptide consists of serine.

31. The composition of claim 28, wherein the polypeptide consists of lysine.

32. The composition of claims 26, 27, 28, 29, 30, or 31 wherein said active agent is attached through the N-terminus.

33. The composition of claims 26, 27, 28, 30, or 31 wherein said active agent is attached through the side chain of an amino acid.

34. A method for delivering an active agent to a patient comprising: orally administering to said patient a composition comprising a polypeptide wherein the polypeptide consists of one or more of the twenty naturally occurring amino acids, covalently attached to an active agent other than an amino acid through an alcohol, an amine or a carboxylic acid functionality, in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration wherein said composition is in the form of an ingestible tablet, a capsule, or an oral suspension.

35. The method of claim 34, wherein said active agent is attached through the C-terminus.

36. The method of claim 35, wherein said active agent is an alcohol which is attached through a hydroxyl group.

37. The method of claim 35, wherein said active agent is an amine which is attached through an amine group.

38. The method of claim 34, wherein said active agent is attached through the N-terminus.

39. The method of claim 38, wherein said active agent is an alcohol which is attached through a hydroxyl group.

40. The method of claim 38, wherein said active agent is a carboxylic acid which is attached through an acid group.

41. The method of claim 34, wherein said active agent is attached through the side chain of an amino acid.

42. The method of claim 41, wherein said active agent is an alcohol which is attached through a hydroxyl group.

43. The method of claim 41, wherein said active agent is an amine which is attached through an amine group.

44. The method of claim 41, wherein said active agent is a carboxylic acid which is attached through an acid group.

45. The method of any one of claims 35-37, 39, or 40-44 wherein the polypeptide consists of glutamic acid.

46. The method of any one of claims 35-37, 39, or 40-44 wherein the polypeptide consists of serine.

47. The method of any one of claims 35-37, 39, or 40-44, wherein the polypeptide consists of lysine.

48. A composition comprising: a polypeptide wherein said polypeptide is a heteropolymer of two or more synthetic amino acids; an active agent other than an amino acid covalently attached to said polypeptide; and wherein said composition is in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration wherein said composition is in the form of an ingestible tablet, a capsule, or an oral suspension.

49. Composition of claim 48, wherein said active agent is attached to the N-terminus.

50. Composition of claim 48, wherein said active agent is attached to the C-terminus.

51. Composition of claim 48, wherein said active agent is attached to the side chain.

52. A composition comprising: a polypeptide; an active agent other than an amino acid covalently attached to said polypeptide in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration wherein said composition is in the form of an ingestible tablet, a capsule, or an oral suspension.

53. The composition of claim 52, wherein said polypeptide comprises one or more of the twenty naturally occurring amino acids.

54. The composition of claim 52, wherein said polypeptide comprises glutamic acid, aspartic acid, arginine, asparagine, cysteine, lysine, threonine, or serine.

55. The composition of claim 54, wherein the polypeptide comprises glutamic acid.

56. The composition of claim 54, wherein the polypeptide comprises serine.

57. The composition of claim 54, wherein the polypeptide comprises lysine.

58. The composition of claims 52, 53, 54, 55, 56, or 57 wherein said active agent is attached through the C-terminus.

59. The composition of claims 52, 53, 54, 55, 56, or 57 wherein said active agent is attached through the N-terminus.

60. The composition of claims 52, 53, 54, 55, 56, or 57 wherein said active agent is attached through the side chain of an amino acid.

61. A composition comprising: a polypeptide consisting essentially of one or more of the twenty naturally occurring amino acids; an active agent other than an amino acid covalently attached to said polypeptide in a form suitable for oral administration and enzymatic release of said active agent into the bloodstream following oral administration wherein said composition is in the form of an ingestible tablet, a capsule, or an oral suspension.

62. The composition of claim 61, wherein said naturally occurring amino acid is glutamic acid.

63. The composition of claim 61, wherein said naturally occurring amino acid is lysine.

64. The composition of claim 61, wherein said naturally occurring amino acid is serine.
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