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Details for Patent: 6,677,492

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Details for Patent: 6,677,492

Title: Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid
Abstract:The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.
Inventor(s): Bieniarz; Christopher (Highland Park, IL), Chang; Steve H. (Gurnee, IL), Cromack; Keith R. (Lake Bluff, IL), Huang; Shuyen L. (Riverwoods, IL), Kawai; Toshikazu (Saitama, JP), Kobayashi; Manami (Saitama, JP), Loffredo; David (Elmhurst, IL), Raghavan; Rajagopalan (Grayslake, IL), Speicher; Earl R. (Buffalo Grove, IL), Stelmach; Honorats A. (Lake Forest, IL)
Assignee: Abbott Laboratories (Abbott Park, IL)
Filing Date:Jul 03, 2002
Application Number:10/190,271
Claims:1. A method for storing a quantity of sevoflurane, the method comprising the steps of: providing a container defining an interior space, said container having an interior wall adjacent said interior spaced defined by said container; providing a quantity of sevoflurane; coating said interior wall of said container with a Lewis acid inhibitor; placing said quantity of sevoflurane in said interior space defined by said container.

2. A method for storing a quantity of sevoflurane in accordance with claim 1, wherein said Lewis acid inhibitor is selected from the group consisting of water, butylated hydroxytoluene, methylparaben, propylparaben, propofol, and thymol.

3. A method for storing a quantity of sevoflurane in accordance with claim 1, wherein said Lewis acid inhibitor is water.

4. A method for storing a quantity of sevoflurane in accordance with claim 1, wherein said Lewis acid inhibitor is water saturated sevoflurane.

5. The method of claim 1 wherein the step of coating said interior wall of said container is accomplished by washing or rinsing said interior wall of said container with said Lewis acid inhibitor prior to filling said container with said quantity of sevoflurane.

6. The method of claim 5 wherein said Lewis acid inhibitor is water.

7. A method for storing a quantity of sevoflurane in accordance with claim 5, wherein said Lewis acid inhibitor is water saturated sevoflurane.

8. The method of claim 6 wherein said container is partially dried between the rinsing and filling steps.

9. The method of claim 2 wherein the step of coating said interior wall of said container is accomplished by placing said container in a humidity chamber for a sufficient time to allow said Lewis acid inhibitor to accumulate in said container in an amount effective to prevent degradation by a Lewis acid of said quantity of sevoflurane.

10. The method of claim 9 wherein said Lewis acid inhibitor is water.

11. A sevoflurane product protected from degradation by Lewis acids in accordance with the method of claim 1.

12. A sevoflurane product protected from degradation by Lewis acids in accordnace with the method of claim 2.

13. A sevoflurane product protected from degradation by Lewis acids in accordnace with the method of claim 3.

14. A sevoflurane product protected from degradation by Lewis acids in accordnace with the method of claim 4.
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