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Details for Patent: 6,663,887

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Details for Patent: 6,663,887

Title: Compounds and compositions for delivering active agents
Abstract:Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Inventor(s): Leone-Bay; Andrea (Ridgefield, CT), Paton; Duncan R. (Purdys, NY), Ho; Koc-Kan (Mt. Kisco, NY), DeMorin; Frenel (Spring Valley, NY)
Assignee: Emisphere Technologies, Inc. (Tarrytown, NY)
Filing Date:Feb 21, 2002
Application Number:10/090,012
Claims:1. A composition comprising: (a) a compound having the formula ##STR14## or a salt thereof; and (b) an active agent that is a peptide.

2. A composition as defined in claim 1, wherein the active agent is a pharmacological agent or a therapeutic agent.

3. A composition as defined in claim 1, wherein the active agent is a monoclonal antibody.

4. A composition comprising: (a) a compound having the formula ##STR15## or a salt thereof; and (b) an active agent that is a polysaccharide.

5. A composition as defined in claim 4, wherein the active agent is a pharmacological agent or a therapeutic agent.

6. A composition comprising: (a) a compound having the formula ##STR16## or a salt thereof; and (b) an active agent that is a mucopolysaccharide.

7. A composition as defined in claim 6, wherein the active agent is a pharmacological agent or a therapeutic agent.

8. A composition comprising: (a) a compound having the formula ##STR17## or a salt thereof; and (b) an active agent that is a carbohydrate.

9. A composition as defined in claim 8, wherein the active agent is a pharmacological agent or a therapeutic agent.

10. A composition comprising: (a) a compound having the formula ##STR18## or a salt thereof; and (b) an active agent that is a lipid.

11. A composition as defined in claim 10, wherein the active agent is a pharmacological agent or a therapeutic agent.

12. A composition comprising: (a) a compound having the formula ##STR19## or a salt thereof; and (b) an active agent selected from the group consisting of a hormone, an anti-microbial agent and an anti-fungal agent.

13. A composition as defined in claim 12, wherein the active agent is selected from the group consisting of interleukin-I, insulin, and growth hormone-releasing hormone.

14. A composition as defined in claim 13, wherein the active agent is interleukin-I.

15. A composition as defined in claim 13, wherein the active agent is insulin.

16. A composition as defined in claim 13, wherein the active agent is growth hormone-releasing hormone.

17. A composition comprising: (a) a compound having the formula ##STR20## or a salt thereof; and (b) cromolyn sodium.

18. A dosage unit form comprising (a) a compound having the formula ##STR21## or a salt thereof; (b) a biologically active agent; and (c) (i) an excipient, (ii) a diluent, (iii) a disintegrant, (iv) a lubricant, (v) a plasticizer, (vi) a colorant, (vii) a dosing vehicle, or (viii) any combination thereof.

19. A dosage unit form as defined in claim 18, wherein the biologically active agent is a peptide.

20. A dosage unit form as defined in claim 18, wherein the biologically active agent is a polysaccharide.

21. A dosage unit form as defined in claim 18, wherein the biologically active agent is a mucopolysaccharide.

22. A dosage unit form as defined in claim 18, wherein the biologically active agent is a carbohydrate.

23. A dosage unit form as defined in claim 18, where the biologically active agent is a lipid.

24. A dosage unit form as defined in claim 18, wherein the biologically active agent is an anti-microbial agent.

25. A dosage unit form as defined in claim 18, wherein the biologically active agent is a monoclonal antibody.

26. A dosage unit form as defined in claim 18, wherein the biologically active agent is a hormone.

27. A dosage unit form as defined in claim 18, wherein the biologically active agent is an anti-fungal agent.

28. A dosage unit form as defined in claim 18, wherein the biologically active agent is selected from the group consisting of interleukin-I, insulin, and growth hormone-releasing hormone.

29. A dosage unit form as defined in claim 28, wherein the biologically active agent is interleukin-I.

30. A dosage unit form as defined in claim 28, wherein the biologically active agent is insulin.

31. A dosage unit form as defined in claim 28, wherein the biologically active agent is a growth hormone-releasing hormone.

32. A dosage unit form as defined in claim 18, comprised of a tablet, a capsule, or a liquid.

33. A dosage unit form comprising (a) a compound having the formula ##STR22## or a salt thereof; and (b) cromolyn sodium.

34. A dosage unit form as defined in claim 33, comprised of a tablet, a capsule or a liquid.

35. A method of administering a biologically active agent to an animal in need of the agent, the method comprising administering orally to the animal a dosage unit form as defined in claim 18.

36. A method of administering cromolyn sodium to an animal in need thereof, the method comprising administering orally to the animal a dosage unit form as defined in claim 33.

37. A method of administering a biologically active agent to an animal in need of the agent, the method comprising administering orally to the animal a dosage unit form as defined in claim 19.

38. A method of administering a biologically active agent to an animal in need of the agent, the method comprising administering orally to the animal a dosage unit form as defined in claim 20.

39. A method of administering a biologically active agent to an animal in need of the agent, the method comprising administering orally to the animal a dosage unit form as defined in claim 21.

40. A method of administering a biologically active agent to an animal in need of the agent, the method comprising administering orally to the animal a dosage unit form as defined in claim 22.

41. A method of administering a biologically active agent to an animal in need of the agent, the method comprising administering orally to the animal a dosage unit form as defined in claim 23.

42. A method of administering interleukin-I to an animal in need of interleukin-I, the method comprising administering orally to the animal a dosage unit form as defined in claim 29.

43. A method of administering insulin to an animal in need of insulin, the method comprising administering orally to the animal a dosage unit form as defined in claim 30.

44. A method of administering growth hormone-releasing hormone to an animal in need of growth hormone-releasing hormone, the method comprising administering orally to the animal a dosage unit form as defined in claim 31.
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