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Details for Patent: 6,638,767

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Details for Patent: 6,638,767

Title: Methods for delivering compounds into a cell
Abstract:The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.
Inventor(s): Unger; Evan C. (Tucson, AZ), McCreery; Thomas (Tucson, AZ)
Assignee: ImaRx Pharmaceutical Corporation (Tucson, AZ)
Filing Date:Dec 21, 2000
Application Number:09/742,938
Claims:1. A method of expression an exogenous nucleic acid sequence in a cell, the method comprising the steps of: delivering said exogenous nucleic acid sequence together with a halide compound into said cell; and applying ultrasound to said cell sufficient to express said exogenous nucleic acid sequence in said cell, wherein said delivering and said applying steps are conducted concurrently.

2. A method of expressing an exogenous nucleic acid sequence in a cell, said method comprising the steps of: delivering said exogenous nucleic acid sequence together with a halide compound into said cell; and applying ultrasound to said cell sufficient to facilitate expression of said exogenous nucleic acid sequence in said cell, wherein said halide compound is selected from the group consisting of 1-bromo-nonafluorobutane; perfluorooctyliodide; perfluorooctylbromide; 1-chloro-1-fluoro-1-bromomethane; 1,1,1-trichloro-2,2,2-trifluoroethane; 1,2-dichloro-2,2-difluoroethane; 1,1-dichloro-1,2-difluoroethane; 1,2-dichloro-1,1,3-trifluoropropane; 1-bromoperfluorobutane; 1-bromo-2,4-difluorobenzene; 2-iodo-1,1,1-trifluoroethane; 5-bromovaleryl chloride; 1,3-dichlorotetrafluoroacetone; bromine pentafluoride; 1-bromo-1,1,2,3,3,3-hexafluoropropane; 2-chloro 1,1,1,4,4,4-hexafluoro-2-butene; 2-chloropentafluoro-1,3-butadiene; iodotrifluoroethylene; 1,1,2-trifluoro-2-chloroethane; 1,2-difluorochloroethane; 1,1-difluoro-2-chloroethane; 1,1-dichlorofluoroethane; heptafluoro-2-iodopropane; bromotrifluoroethane; chlorotrifluoromethane; dichlorodifluoromethane; dibromofluoromethane; chloropentafluorethane; bromochlorodifluoromethane; dichloro-1,1,2,2-tetrafluoroethane; 1,1,1,3,3-pentafluoropentane; perfluorotributylamine; perfluorotripropylamine; 3-fluorobenzaldehyde; 2-fluoro-5-nitrotoluene; 3-fluorostyrene; 3,5-difluoroaniline; 2,2,2-trifluoroethylacrylate; 3-(trifluoromethoxy)-acetophenone; 1,1,2,2,3,3,4,4-octafluorobutane; 1,1,1,3,3-pentafluorobutane; 1-fluorobutane; 1,1,2,2,3,3,4,4-octafluorobutane; 1,1,1,3,3-pentafluorobutane; perfluoro-4 methylquinolizidine; perfluoro-N-methyl-decahydroquinone; perfluoro-N-methyl-decahydroisoquinone; perfluoro-N-cyclohexyl-pyrrolidine; tetradecaperfluoroheptane; dodecaperfluorocyclohexane; perfluoromethane; perfluoroethane; perfluoropane; perfluorobutane; perfluoropentane; perfluorohexane; perfluoroheptane; perfluorooctane; perfluorononane; perfluorodecane; perfluorododecane; perfluoro-2-methyl-2-pentene; perfluorocyclohexane; perflurodecalin; perfluorododecalin; perfluoropropylene; perfluorocyclobutane; perfluoro-2-butyne; perfluoro-2-butene; perfluorobuta-1,3-diene; perfluorobutylethyl ether; bis(perfluoroisopropyl) ether; bis(perfluoropropy) ether; perfluorotetrahydropyran; perfluoromethyl tetrahydrofuran; perfluoro t-butyl methyl ether; perfluoro isobutyl methyl ether; perfluoro n-butyl methyl ether; perfluoro isopropyl ethyl ether; perfluoro n-propyl ethyl ether; perfluoro cyclobutyl methyl ether; perfluoro cyclopropyl ethyl ether; perfluoro isopropyl methyl ether; perfluoro n-propyl methyl ether; perfluoro diethyl ether; perfluoro cyclopropyl methyl ether; perfluoro methyl ethyl ether; perfluoro dimethyl ether; sulfur hexafluoride; and selenium hexafluoride; wherein said delivering and said applying steps are conducted concurrently.

3. A method of expressing an exogenous nucleic acid sequence in a cell, the method comprising the steps of: delivering said exogenous nucleic acid sequence together with a halide compound into said cell; and applying ultrasound to said cell sufficient to express said exogeneous nucleic acid sequence in said cell, wherein said delivering step is preceded by said applying step.

4. A method of expressing an exogenous nucleic acid sequence in a cell, said method comprising the steps of: delivering said exogenous nucleic acid sequence together with a halide compound into said cell; and applying ultrasound to said cell sufficient to facilitate expression of said exogenous nucleic acid sequence in said cell, wherein said halide compound is selected from the group consisting of 1-bromo-nonafluorobutane; perfluorooctyliodide; perfluorooctylbromide; 1-chloro-1-fluoro-1-bromomethane; 1,1,1-trichloro-2,2,2-trifluoroethane; 1,2-dichloro-2,2-difluoroethane; 1,1-dichloro-1,2-difluoroethane; 1,2-dichloro-1,1,3-trifluoropropane; 1-bromoperfluorobutane; 1-bromo-2,4-difluorobenzene; 2-iodo-1,1,1-trifluoroethane; 5-bromovaleryl chloride; 1,3-dichlorotetrafluoroacetone; bromine pentafluoride; 1-bromo-1,1,2,3,3,3-hexafluoropropane; 2-chloro 1,1,1,4,4,4-hexafluoro-2-butene; 2-chloropentafluoro-1,3-butadiene; iodotrifluoroethylene; 1,1,2-trifluoro-2-chloroethane; 1,2-difluorochloroethane; 1,1-difluoro-2-chloroethane; 1,1-dichlorofluoroethane; heptafluoro-2-iodopropane; bromotrifluoromethane; chlorotrifluoromethane; dichlorodifluoromethane; dibromofluoromethane; chloropentafluoroethane; bromochlorodifluoromethane; dichloro-1,1,2,2-tetrafluoroethane; 1,1,1,3,3-pentafluoropentane; perfluorotributylamine; perfluorotripropylamine; 3-fluorobenzaldehyde; 2-fluoro-5-nitrotoluene; 3-fluorostyrene; 3,5-difluoroaniline; 2,2,2-trifluoroethylacrylate; 3-(trifluoromethoxy)-acetophenone; 1,1,2,2,3,3,4,4-octafluorobutane; 1,1,1,3,3-pentafluorobutane; 1-fluorobutane; 1,1,2,2,3,3,4,4-octafluorobutane; 1,1,1,3,3-pentafluorobutane; perfluoro-4 methylquinolizidine; perfluoro-N-methyl-decahydroquinone; perfluoro-N-methyl-decahydroisoquinone; perfluoro-N-cyclohexyl-pyrrolidine; tetradecaperfluoroheptane; dodecaperfluorocyclohexane; perfluoromethane; perfluorethane; perfluoropropane; perfluorobutane; perfluoropentane; perfluorohexane; perfluoroheptane; perfluorooctane; perfluorononane; perfluorodecane; perfluorodecane; perfluoro-2-methyl-2-pentene; perfluorocyclohexane; perfluorodecalin; perfluorododecalin; perfluoropropylene; perfluorocyclobutane; perfluoro-2-butyne; perfluoro-2-butene; perfluorobuta-1,3-diene; perfluorobutyethyl ether; bis(perfluoroisopropyl) ether; bis(perfluoropropyl) ether; perfluorotetrahydropyran; perfluoromethyl tetrahydrofuran; perfluoro t-butyl methyl ether; perfluoro isobutyl methyl ether; perfluoro n-butyl methyl ether; perfluoro isopropyl ethyl ether; perfluoro n-propyl ethyl ether; perfluoro cyclobutyl methyl ether; perfluoro cyclopropyl ethyl ether; perfluoro isopropyl methyl ether; perfluoro n-propyl methyl ether; perfluoro diethyl ether; perfluoro cyclopropyl methyl ether; perfluoro methyl ethyl ether; perfluoro dimethyl ether; sulfur hexafluoride; and selenium hexafluoride; wherein said delivering step is preceded by said applying step.
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