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|Abstract:||A pharmaceutical composition in the form of a solid dispersion comprising a macrolide, e.g. a rapamycin or an ascomycin, and a carrier medium.|
|Inventor(s):||Guitard; Patrice (Hegenheim, FR), Haeberlin; Barbara (Riehen, CH), Link; Rainer (Staufen, DE), Richter; Friedrich (Grenzach-Wyhlen, DE)|
|Assignee:||Novartis AG (Basel, CH)|
|Filing Date:||Jul 12, 2002|
|Claims:||1. A pharmaceutical composition in the form of a solid dispersion comprising 33-epichloro-33-desoxy-ascomycin and a carrier medium, wherein the pharmaceutical composition does not contain a surfactant. |
2. The pharmaceutical composition according to claim 1 wherein the carrier medium comprises a water-soluble polymer or a cyclodextrin.
3. The pharmaceutical composition according to claim 2 wherein the water-soluble polymer is hydroxypropylmethylcellulose or polyvinylpyrrolidone.
4. The pharmaceutical composition according to claim 2 wherein the water-soluble polymer is present in an amount up to 95 weight percent, based on the total weight of the composition.
5. The pharmaceutical composition according to claim 1 wherein the ascomycin is present in an amount of up to 30 weight percent, based on the total weight of the composition.
6. The pharmaceutical composition according to claim 1 wherein the ascomycin is in amorphous form.
7. The pharmaceutical composition according to claim 1 which additionally comprises an antioxidant.
8. The pharmaceutical composition according to claim 7 wherein the antioxidant is selected from the group consisting of butylated hydroxytoluene, DL-.alpha.-tocopherol, propyl gallate, ascorbyl palmitate, fumaric acid, and combinations thereof.
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