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Details for Patent: 6,596,710

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Details for Patent: 6,596,710

Title: Dosage forms of risedronate
Abstract:The present invention is directed to a novel enteric-coated oral dosage form of a risedronate active ingredient comprised of a safe and effective amount of a pharmaceutical compostion which is comprised of a risedronate active ingredient and pharmaceutically-acceptable excipients. Said dosage forms prohibit the exposure of the risedronate active ingredient to the epithelial and mucosal tissues of the buccal cavity, pharynx, esophagus, and stomach and thereby protects said tissues from erosion, ulceration or other like irritation. Accordingly, the said dosage forms effect the delivery to the lower intestinal tract of said human or other mammal of a safe and effective amount of the risedronate active ingredient, and substantially alleviate the esophagitis or esophageal irritation which sometimes accompanies the oral administration of risedronate active ingredients.
Inventor(s): Dansereau; Richard John (Sherburne, NY), Mosher; Russell Youker (Norwich, NY), Axelrod; Douglas Wayne (Norwich, NY), Sietsema; William Kendall (Norwich, NY)
Assignee: The Procter & Gamble Company (Cincinnati, OH)
Filing Date:Jun 09, 2000
Application Number:09/591,911
Claims:1. A pharmaceutical composition comprising, from 0.15% to 40.00% by weight of a diphosphonate compound selected from the group consisting of: 2-(3-pyridyl)-ethane-1,1-diphonphonic acid; 2-(4-pryidyl)-ethane-1,1-diphosphonic acid; 2-(2-pyrdily)-hydroxethane-1,1-diphosphonic acid; 2-(3-pyridyl)-hydroxyethane-1-1,diphosphonic acid; and 2-(4-pyridyl)-hydroxyethan-1,1-diphosphonic and from 60.00% to 99.75% by weight of excipients comprising: lactose, microcrystalline cellulose, crospovidone, and magnesium stearate.
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