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|Title:||Methods for treating irritable bowel syndrome|
|Abstract:||This invention relates to the use of 5-HT3 receptor antagonists in the treatment of nonconstipated female IBS patients.|
|Inventor(s):||Mangel; Allen Wayne (Chapel Hill, NC), Northcutt; Allison Ruth (Raleigh, NC)|
|Assignee:||SmithKline Beecham Corporation (Philadelphia, PA)|
|Filing Date:||Jun 10, 2002|
|Claims:||1. A method for improving bowel movement frequency in non-constipated female IBS which comprises administering an effective amount of a 5-HT.sub.3 receptor antagonist or a pharmaceutically acceptable derivative thereof. |
2. The method according to claim 1, wherein the 5-HT.sub.3 receptor antagonist is alosetron or a pharmaceutically acceptable derivative thereof.
3. The method according to claim 2, wherein alosetron is in the form of its hydrochloride.
4. The method according to claim 1, wherein the 5-HT.sub.3 receptor antagonist is selected from granisetron, azasetron, tropisetron, ramosetron, ondansetron, lerisetron, (R) zacopride, cilansetron, itasetron, indisetron and dolasetron.