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Details for Patent: 6,589,536

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Details for Patent: 6,589,536

Title: Soft gelatin capsule manufacture
Abstract:Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a migrateable solvent such as 1,2-propyleneglycol as a solvent in the capsule filling and in the capsule shell. The manufacture of said capsules is improved, if in the process for making the soft gelatin capsules the gelatin bands are cooled with a liquid, and preferably with water.
Inventor(s): Brox; Werner (Beerfelden, DE), Meinzer; Armin (Freiburg, DE), Zande; Horst (Schonbru, DE)
Assignee: Novartis AG (Basel, CH)
Filing Date:Feb 07, 2000
Application Number:09/499,497
Claims:1. A soft gelatin capsule comprising a shell and a filling wherein said shell comprises polyethylene glycol and gelatin at the time of encapsulation, and said filling comprises cyclosporin and polyethylene glycol at the time of encapsulation, wherein the polyethylene glycol is present in the shell after drying in an amount of from 2 to 40 weight percent, based on the weight of the shell.

2. The soft gelatine capsule according to claim 1 wherein the polyethylene glycol has a molecular weight of from 200 to 600.

3. The soft gelatine capsule according to claim 1 wherein the polyethylene glycol in the shell after drying is present in an amount of from 5 to 32 weight percent.

4. The soft gelatine capsule according to claim 1 wherein the shell additionally comprises a plasticizer.

5. The soft gelatine capsule according to claim 1 wherein the filling additionally comprises a lipophilic component.

6. The soft gelatine capsule according to claim 1 wherein the filling additionally comprises a surfactant.

7. The soft gelatine capsule according to claim 1 wherein the filling additionally comprises a mixture of C.sub.12 -C.sub.20 fatty acid mono-, di-, and tri-glycerides.

8. The soft gelatine capsule according to claim 1 wherein the filling additionally comprises a polyoxyethylene-glycol hydrogenated castor oil.

9. The soft gelatine capsule according to claim 1 wherein the filling additionally comprises ethanol.

10. The soft gelatine capsule according to claim 1 wherein the filling is a liquid.
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