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Generated: August 21, 2017

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Title: Film-coated tablet for improved upper gastrointestinal tract safety
Abstract:A novel oral dosage to be delivered to the stomach comprising a safe and effective amount of an active ingredient selected from the group consisting of emepronium bromidebromide, doxycycline, and other tetracyclines/antibiotics, iron preparations, quinidine, nonsteroidal anti-inflammatory drugs, alprenolol, ascorbic acid, captopril, theophylline, zidovoudine (AZT), bisphosphonates and mixtures thereof and pharmaceutically-acceptable excipients, wherein said oral dosage form is a generally oval form and film coated to facilitate rapid esophageal transit and avoid irritation in the mouth, buccal cavity, pharynx, and esophagus.
Inventor(s): Dansereau; Richard John (Mason, OH), Bekker; Petrus Jakobus (Cincinnati, OH)
Assignee: The Procter & Gamble Company (Cincinnati, OH)
Filing Date:Oct 23, 2000
Application Number:09/694,799
Claims:1. An oral dosage form to be delivered to the stomach said dosage form comprising a safe and effective amount of alprenolol and pharmaceutically-acceptable excipients, wherein said oral dosage form is oval shaped, about 0.23 to about 0.85 inches in length, about 0.11 to about 0.4 inches in width, and about 0.075 to about 0.3 inches in thickness and said oral dosage form is film coated to facilitate rapid esophageal transit and avoid irritation in the mouth, buccal cavity, pharynx, and esophagus wherein said film coating allows for delivery of said alprenolol to the stomach.

2. A dosage form according to claim 1 wherein the film coating is soluble at pH from about 1.2 to about 5.

3. A dosage form according to claim 2 wherein said film coating is selected from the group consisting of hydroxypropylmethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, methylcellulose, ethylcellulose, acrylic resins, polyvinylpyrrolidone or gelatin or mixtures thereof.

4. A dosage form according to claim 1 wherein said film coating is selected from the group consisting of hydroxypropylmethylcellulose and hydroxypropylcellulose.

5. An oral dosage form according to claim 1 wherein said dosage form is a compressed tablet comprising particles of alprenolol and pharmaceutically-acceptable excipients.

6. An oral dosage form according to claim 5 wherein said particles of alprenolol are themselves film coated.

7. An oral dosage form according to claim 4 wherein the length is about 0.455 inches, the width of about 0.255 inches and the thickness about 0.157 inches.
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Harvard Business School
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