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Details for Patent: 6,554,818

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Details for Patent: 6,554,818

Title: Method of filling a drug capsule and article produced thereby
Abstract:A needleless injector drug capsule assembly comprising a container, a housing therefor, a piston, and resilient seals to permit filling and sealing thereafter to maintain sterility of the contents. A seal carrier holds a seal through which filling of the capsule is carried out via its outlet orifice, and after filling the seal carrier is closed off, for example by a plug or by heat sealing.
Inventor(s): Weston; Terence Edward (Eye, GB), Walker; John Nicholas (Frodsham, GB)
Assignee: Weston Medical Limited (Suffolk, GB)
Filing Date:Dec 07, 2000
Application Number:09/732,168
Claims:1. A method of filling a needleless injector capsule with a drug in liquid form, and sealing the capsule after filling, the capsule defining a chamber, and a seal carrier having a seal, wherein the chamber communicates with a region exterior to the capsule, prior to sealing, via an orifice in the capsule wall and an orifice in the seal held in the seal carrier, wherein the seal is in sealing contact with the capsule wall around the orifice in the capsule wall, and wherein the capsule is retained in a housing and the seal carrier is removably attached to the housing, or the seal carrier is removably attached to the capsule, the method comprising: (a) introducing liquid into the chamber via the seal orifice and the capsule orifice, and (b) closing off the seal orifice to communication with said region by a plug inserted in the seal carrier.

2. A method according to claim 1, wherein the seal carrier is frangibly attached to the housing or capsule.

3. A method according to claim 1, wherein the housing is present and is moulded on to the capsule.

4. A method according to claim 1, wherein the seal carrier is in the form of a tube.

5. A method according to claim 1, wherein the capsule chamber has a movable piston received therein and wherein during step (a) introduction of the liquid into the chamber causes the piston to move away from the orifice in the capsule wall.

6. A method of filling a needleless injector capsule with a drug in liquid form, and sealing the capsule after filling, the capsule defining a chamber, and a seal carrier having a seal, wherein the chamber communicates with a region exterior to the capsule, prior to sealing, via an orifice in the capsule wall and an orifice in the seal held in the seal carrier, wherein the seal is in sealing contact with the capsule wall around the orifice in the capsule wall, and wherein the capsule is retained in a housing and the seal carrier is removably attached to the housing, or the seal carrier is removably attached to the capsule, the method comprising: (a) introducing liquid into the chamber via the seal orifice and the capsule orifice, and (b) closing off the seal orifice to communication with said region by inserting a plug in the seal orifice.

7. A method of filling a needleless injector capsule with a drug in liquid form, and sealing the capsule after filling, the capsule defining a chamber, and a seal carrier having a seal, wherein the chamber communicates with a region exterior to the capsule, prior to sealing, via an orifice in the capsule wall and an orifice in the seal held in the seal carrier, wherein the seal is in sealing contact with the capsule wall around the orifice in the capsule wall, and wherein the capsule is retained in a housing and the seal carrier is removably attached to the housing, or the seal carrier is removably attached to the capsule, the method comprising: (a) introducing liquid into the chamber via the seal orifice and the capsule orifice, and (b) closing off the seal orifice to communication with said region by deforming the seal carrier.

8. A method according to claim 7, wherein the seal carrier is deformed by the action of heat.
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