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Details for Patent: 6,537,522

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Details for Patent: 6,537,522

Title: Neuroprobes for mapping monoamine reuptake sites
Abstract:Iodinated neuroprobes for mapping monoamine reuptake sites in the brain, and particularly iodinated neuroprobes that can also serve as radiotracers for use in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging of such reuptake sites, are disclosed. Precursors of radiolabeled iodinated neuroprobes, both with and without a radiotracer atom, and kits for preparing the radiolabeled iodinated neuroprobes are also disclosed.
Inventor(s): Neumeyer; John L. (Wayland, MA), Milius; Richard A. (Boston, MA), Innis; Robert B. (Hamden, CT), Tamagnan; Gilles (Woodbridge, CT), Wang; Shaoyin (Lexington, MA)
Assignee: Amersham PLC (Amersham, GB)
Filing Date:May 12, 1998
Application Number:09/076,288
Claims:1. An intermediate useful in the synthesis of a neuroprobe for mapping monoamine reuptake sites, the intermediate being of the formula: ##STR4##

wherein R'=a C.sub.w H.sub.2w+1 group where w=0-6, a p-iodophenylmethyl group, a p-iodophenylethyl group, a phenylmethyl group, or a phenylethyl group; X=an isotope of I; and Y=H.

2. An intermediate useful in the synthesis of a neuroprobe for mapping monoamine reuptake sites, the intermediate being of the formula: ##STR5##

wherein R'=a C.sub.w H.sub.2w+1 group where w=0-6, a p-iodophenylmethyl group, a p-iodophenylethyl group, a phenylmethyl group, or a phenylethyl group; X an isotope of I; and Y=H.

3. The intermediate of claim 1, wherein R'=a C.sub.w H.sub.2w+1 group where w=1; X=an isotope of I; and Y=H,

said intermediate being denominated nor-.beta.-CIT.
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