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Generated: September 20, 2017

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Title: Retroviral protease inhibiting compounds
Abstract:A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
Inventor(s): Kempf; Dale J. (Libertyville, IL), Norbeck; Daniel W. (Crystal Lake, IL)
Assignee: Abbott Laboratories (Abbott Park, IL)
Filing Date:Jul 20, 2000
Application Number:09/619,785
Claims:1. An acylating compound of the formula: ##STR18##

wherein R.sub.6 is hydrogen or loweralkyl; R.sub.7 is thiazolyl, oxazolyl, isoxazolyl or isothiazolyl wherein the thiazolyl, oxazolyl, isoxazolyl or isothiazolyl ring is unsubstituted or substituted with loweralkyl; and L is an activating group for an acylation reaction, with the proviso that when R.sub.6 is hydrogen and R.sub.7 is 5-thiazolyl, L is other than p-nitrophenyl.

2. The compound of claim 1 wherein R.sub.6 is hydrogen and R.sub.7 is thiazolyl, oxazolyl, isoxazolyl or isothiazolyl.

3. The compound of claim 1 wherein R.sub.6 is hydrogen and R.sub.7 is 5-thiazolyl, 5-oxazolyl, 5-isoxazolyl or 5-isothiazolyl.

4. The compound of claim 1 wherein L is p-nitrophenyl, phenyl, N-succinimidyl, N-phthalimidyl, N-benzotriazolyl, N-5-norbornene-2,3-carboxamidyl or 2,4,5-trichlorophenyl.

5. An acylating compound of the formula: ##STR19##

wherein L is an activating group for an acylation reaction, with the proviso that L is other than p-nitrophenyl.

6. The compound of claim 5 wherein L is phenyl, N-succinimidyl, N-phthalimidyl, N-benzotriazolyl, N-5-norbornene-2,3-carboxamidyl or 2,4,5-trichlorophenyl.

7. The compound of claim 5 wherein L is phenyl.

8. The compound of claim 5 wherein L is N-succinimidyl.

9. The compound of claim 5 wherein L is N-phthalimidyl.

10. The compound of claim 5 wherein L is N-benzotriazolyl.

11. The compound of claim 5 wherein L is N-5-norbornene-2,3-carboxamidyl.

12. The compound of claim 5 wherein L is 2,4,5-trichiorophenyl.
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