|Title:||Devices compositions and methods for the pulmonary delivery of aerosolized medicaments|
|Abstract:||According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by weight (% w) water, usually below about 5% w and preferably less than about 3% w; a particle size of about 1.0-5.0 .mu.m mass median diameter (MMD), usually 1.0-4.0 .mu.m MMD, and preferably 1.0-3.0 .mu.m MMD; a delivered dose of about >30%, usually >40%, preferably >50%, and most preferred >60%; and an aerosol particle size distribution of about 1.0-5.0 .mu.m mass median aerodynamic diameter (MMAD), usually 1.5-4.5 .mu.m MMAD, and preferably 1.5-4.0 MMAD. Such composition are of pharmaceutical grade purity.|
|Inventor(s):||Platz; Robert M. (Half Moon Bay, CA), Patton; John S. (San Carlos, CA), Foster; Linda (Sunnyvale, CA), Eljamal; Mohammed (San Jose, CA)|
|Assignee:||Inhale Therapeutic Systems, Inc. (San Carlos, CA)|
|Filing Date:||Oct 26, 1999|
|Claims:||1. Biocompatible particles for delivery of a therapeutic, prophylactic or diagnostic agent to the pulmonary system comprising a therapeutic, prophylactic or diagnostic agent wherein the particles have a tap density of 0.34 g/cm.sup.3 and the particles have an MMAD of 1 .mu.m with 90% of the particles <5.0 .mu.m in diameter wherein said agent is alpha-1-antitrypsin. |
2. Biocompatible particles for delivery of a therapeutic, prophylactic or diagnostic agent to the pulmonary system comprising a therapeutic, prophylactic or diagnostic agent which is a protein; wherein the particles have a tap density of 0.34 g/cm.sup.3 and the particles have a diameter of about 1.71 .mu.m MMD and an MMAD of 1 .mu.m with 90% of the particles <5.0 .mu.m in diameter wherein said agent is alpha-1-antitrypsin.
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