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Generated: October 17, 2017

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Title: Antiretroviral enantiomeric nucleotide analogs
Abstract:Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.
Inventor(s): Holy; Antonin (Prague, CZ), Dvorakova; Hana (Prague, CZ), DeClercq; Erik Desire Alice (Lovenjoel, BE), Balzarini; Jan Marie Rene (Heverlee, BE)
Assignee: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic (CZ) N/A (BE) Rega Stichting, V.Z.W. (N/A)
Filing Date:Feb 08, 2000
Application Number:09/500,148
Claims:1. A compound of the formula: ##STR13##

as the enriched or resolved (S) enantiomer.

2. A compound of the formula: ##STR14##

wherein LvO is a leaving group, as a racemate or as the enriched or resolved enantiomers.

3. The compound of claim 2 wherein Lv is toluenesulfonyl.

4. The compound of claim 2 which is the enriched or resolved (R) enantiomer.

5. The compound of claim 2 which is the enriched or resolved (S) enantiomer.

6. A compound of the formula: ##STR15##

as the enriched or resolved (R)enantiomer.
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Serving leading biopharmaceutical companies globally:

Citi
AstraZeneca
Chubb
Harvard Business School
Daiichi Sankyo
Express Scripts
Colorcon
Argus Health
Accenture
UBS

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