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Serving leading biopharmaceutical companies globally:

Harvard Business School
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Generated: February 24, 2018

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Title: Cyclosporin galenic forms
Abstract:Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.
Inventor(s): Cavanak; Thomas (Biel-Benken, CH), Posanski; Ulrich (Freiburg, DE)
Assignee: Novartis AG (Basel, CH)
Filing Date:Aug 16, 2001
Application Number:09/931,680
Claims:1. A pharmaceutical composition for oral administration comprising a cyclosporin as active ingredient in a carrier medium comprising sorbitol mono-, di-, tri-, and tetra-esters of a fatty acid, wherein the fatty acid is obtained from vegetable oil, provided that the cyclosporin is not cyclosporin A.

2. The composition according to claim 1 wherein the vegetable oil is selected from the group consisting of corn oil, almond oil, ground-nut oil, olive oil, palm oil, and combinations thereof.

3. The composition according to claim 2 wherein the vegetable oil is olive oil.

4. The composition according to claim 1 which additionally comprises ethanol.

5. The composition according to claim 1 wherein the carrier medium comprises free sorbitol.

6. The composition according to claim 1 wherein the composition is contained in a capsule.

7. A pharmaceutical composition for oral administration comprising a cyclosporin as active ingredient in a carrier medium comprising a reaction product of a natural or hydrogenated castor oil and ethylene oxide; and sorbitol mono-, di-, tri-, and tetra-esters of a fatty acid, wherein the fatty acid is obtained from vegetable oil, provided that the cyclosporin is not cyclosporin A.
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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
UBS
Daiichi Sankyo
Healthtrust
Fish and Richardson
Fuji
Julphar
Express Scripts
Citi
Mallinckrodt

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