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|Title:||Cyclosporin galenic forms|
|Abstract:||Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.|
|Inventor(s):||Cavanak; Thomas (Biel-Benken, CH), Posanski; Ulrich (Freiburg, DE)|
|Assignee:||Novartis AG (Basel, CH)|
|Filing Date:||Aug 16, 2001|
|Claims:||1. A pharmaceutical composition for oral administration comprising a cyclosporin as active ingredient in a carrier medium comprising sorbitol mono-, di-, tri-, and tetra-esters of a fatty acid, wherein the fatty acid is obtained from vegetable oil, provided that the cyclosporin is not cyclosporin A. |
2. The composition according to claim 1 wherein the vegetable oil is selected from the group consisting of corn oil, almond oil, ground-nut oil, olive oil, palm oil, and combinations thereof.
3. The composition according to claim 2 wherein the vegetable oil is olive oil.
4. The composition according to claim 1 which additionally comprises ethanol.
5. The composition according to claim 1 wherein the carrier medium comprises free sorbitol.
6. The composition according to claim 1 wherein the composition is contained in a capsule.
7. A pharmaceutical composition for oral administration comprising a cyclosporin as active ingredient in a carrier medium comprising a reaction product of a natural or hydrogenated castor oil and ethylene oxide; and sorbitol mono-, di-, tri-, and tetra-esters of a fatty acid, wherein the fatty acid is obtained from vegetable oil, provided that the cyclosporin is not cyclosporin A.
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