Details for Patent: 6,451,776

Title:	Water soluble prodrugs of hindered alcohols
Abstract:	The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.
Inventor(s):	Stella; Valentino J. (Lawrence, KS), Zygmunt; Jan J. (Longmont, CO), Georg; Ingrid Gunda (Lawrence, KS), Safadi; Muhammad S. (Nazareth, IL)
Assignee:	University of Kansas (Lawrence, KS)
Filing Date:	Dec 08, 2000
Application Number:	09/733,817
Claims:	1. A compound selected from the group consisting of: ##STR54## wherein Z is selected from the group consisting of hydrogen, alkali metal ion, and amine; and derivatives and analogues thereof and pharmaceutically acceptable salts thereof. 2. The compound according to claim 1, wherein each Z is independently selected from the group consisting of sodium, tromethamine, triethanolamine, triethylamine, arginine, lysine, ethanolamine and N-methylglucamine. 3. A pharmaceutical composition, comprising: an effective amount of a compound according to claim 1; and a pharmaceutically acceptable carrier. 4. A process for preparing a compound of claim 1, comprising: removing a phosphono protecting group from a compound according to one of ##STR55## wherein Y is the phosphono protecting group; and recovering the product. 5. A method of treatment which comprises administering to a patient in need thereof an effective amount of a compound according to claim 1. 6. The method according to claim 5, wherein said compound is administered orally. 7. The method according to claim 5, wherein said compound is administered parenterally. 8. A camptothecin analogue according to claim 1 selected from the group consisting of Topotecan, Irinotecan, 9-Aminocamptothecin, 9-Nitrocamptothecin and 10-hydroxycamptothecin. 9. A camptothecin derivative according to claim 1 selected from the group consisting of (20)-O-phosphonoxymethylcamptothecin, (20)-O-phosphonoxymethylcamptothecin mono- or di-sodium salt, (20)-O-phosphonoxymethylcamptothecin mono- or di-potassium salt, (20)-O-phosphonoxymethylcamptothecin mono- or di-arginine salt, (20)-O-phosphonoxymethylcamptothecin mono- or di-lysine salt, (20)-O-phosphonoxymethylcamptothecin mono- or di-N-methylglucamine salt and (20)-O-phosphonoxymethylcamptothecin mono- or di-triethanolamine salt.