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Details for Patent: 6,428,780

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Details for Patent: 6,428,780

Title: Compounds and compositions for delivering active agents
Abstract:Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration are provided, and methods of preparation of the modified amino acid compound are provided.
Inventor(s): Leone-Bay; Andrea (Ridgefield, CT), Ho; Koc-Kan (Monmouth Junction, NJ), Sarubbi; Donald J. (Carmel, NY), Milstein; Sam J. (Larchmont, NY), Wang; Nai Fang (Long Island City, NY)
Assignee: Emisphere Technologies, Inc. (Tarrytown, NY)
Filing Date:May 05, 1999
Application Number:09/305,506
Claims:1. A composition comprising: (A) at least one active agent comprising at least one peptide, hormone, polysaccharide, mucopolysaccharide, carbohydrate or lipid; and (B) a compound having the following formula ##STR67##

or a salt thereof.

2. A composition as defined in claim 1, wherein said active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-I, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, vancomycin, parathyroid hormone, and any combination thereof.

3. A composition as defined in claim 2, wherein said active agent comprises an interferon, insulin, heparin, low molecular weight heparin, calcitonin, parathyroid hormone, human growth hormone, growth hormone-releasing hormone, or combinations thereof.

4. A composition as defined in claim 2, wherein said active agent comprises parathyroid hormone.

5. A composition as defined in claim 2, wherein said active agent comprises human growth hormone.

6. A dosage unit form comprising: (A) a composition as defined in claim 1; and (B) (a) an excipient (b) a diluent, (c) a disintegrant, (d) a lubricant, (e) a plasticizer, (f) a colorant, (g) a dosing vehicle, or (h) any combination thereof.

7. A dosage unit form as defined in claim 5, wherein said active agent comprises at least one peptide, hormone, polysaccharide, mucopolysaccharide, carbohydrate, or lipid.

8. A dosage unit form as defined in claim 7, wherein said active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-I, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, vancomycin, parathyroid hormone, and any combination thereof.

9. A dosage unit form as defined in claim 8, wherein said active agent comprises an interferon, insulin, heparin, low molecular weight heparin, calcitonin, parathyroid hormone, human growth hormone, growth hormone-releasing hormone, or combinations thereof.

10. A dosage unit form as defined in claim 6, wherein said active agent comprises parathyroid hormone.

11. A dosage unit form as defined in claim 6, wherein said active agent comprises recombinant human growth hormone.

12. A dosage unit form as defined in claim 6, comprising a tablet, a capsule, or a liquid.

13. A composition as defined in claim 1, wherein said active agent is vancomycin.

14. A method for administering an active agent to an animal in need of said agent, said method comprising administering orally to said animal a composition as defined in claim 1.

15. A method for preparing a composition, said method comprising mixing: (A) at least one active agent comprising at least one peptide, hormone, polysaccharide, mucopolysaccharide, carbohydrate or lipid; (B) at least one compound having the formula ##STR68##

or a salt thereof; and (C) optionally, a dosing vehicle.

16. A method for administering an active agent to an animal in need of the agent, the method comprising administering orally to said animal a composition comprising: (A) at least one active agent; and (B) a compound having the formula ##STR69##

or a salt thereof.

17. The method of claim 16, wherein the active agent is a pharmacological agent or a therapeutic agent.

18. A composition comprising: (A) cromolyn sodium; and (B) a compound having the following formula ##STR70##

or a salt thereof.

19. A dosage unit form comprising: (A) a composition as defined in claim 18; and (B) (a) an excipient (b) a diluent, (c) a disintegrant, (d) a lubricant, (e) a plasticizer, (f) a colorant, (g) a dosing vehicle, or (h) any combination thereof.

20. A composition comprising: (A) desferrioxamine; and (B) a compound having the following formula ##STR71##

or a salt thereof.

21. A dosage unit form comprising: (A) a composition as defined in claim 20; and (B) (a) an excipient (b) a diluent, (c) a disintegrant, (d) a lubricant, (e) a plasticizer, (f) a colorant, (g) a dosing vehicle, or (h) any combination thereof.
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